Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis
Abstract Background Some anti-malarial drugs often cause haemolytic anaemia in glucose-6-phosphate-dehydrogenase deficiency (G6PDd) patients. This study aims to analyse the association of G6PDd and anaemia in malaria patients receiving anti-malarial drugs. Methods A literature search was performed i...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-023-04493-7 |
| _version_ | 1827985154477391872 |
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| author | Erni J. Nelwan Sharifah Shakinah Adeline Pasaribu |
| author_facet | Erni J. Nelwan Sharifah Shakinah Adeline Pasaribu |
| author_sort | Erni J. Nelwan |
| collection | DOAJ |
| description | Abstract Background Some anti-malarial drugs often cause haemolytic anaemia in glucose-6-phosphate-dehydrogenase deficiency (G6PDd) patients. This study aims to analyse the association of G6PDd and anaemia in malaria patients receiving anti-malarial drugs. Methods A literature search was performed in major database portals. All studies searched using keywords with Medical Subject Headings (MeSH) were included, without date or language restriction. Pooled mean difference of haemoglobin and risk ratio of anaemia were analysed using RevMan. Results Sixteen studies comprising 3474 malaria patients that included 398 (11.5%) with G6PDd were found. Mean difference of haemoglobin in G6PDd/G6PD normal (G6PDn) patients was − 0.16 g/dL (95% CI − 0.48, 0.15; I2 5%, p = 0.39), regardless of the type of malaria and dose of drugs. In particular with primaquine (PQ), mean difference of haemoglobin in G6PDd/G6PDn patients with dose < 0.5 mg/kg/day was − 0.04 (95% CI − 0.35, 0.27; I2 0%, p = 0.69). The risk ratio of developing anaemia in G6PDd patients was 1.02 (95% CI 0.75, 1.38; I2 0%, p = 0.79). Conclusion Single or daily standard doses of PQ (0.25 mg/kg/day) and weekly PQ (0.75 mg/kg/week) did not increase the risk of anaemia in G6PDd patients. |
| first_indexed | 2024-04-09T23:10:21Z |
| format | Article |
| id | doaj.art-fbdc7a670af44729be111c45c4d4d6a9 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-09T23:10:21Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-fbdc7a670af44729be111c45c4d4d6a92023-03-22T10:28:56ZengBMCMalaria Journal1475-28752023-03-0122111510.1186/s12936-023-04493-7Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysisErni J. Nelwan0Sharifah Shakinah1Adeline Pasaribu2Division of Tropical and Infectious Disease, Internal Medicine Department, Faculty of Medicine Universitas IndonesiaDivision of Tropical and Infectious Disease, Internal Medicine Department, Faculty of Medicine Universitas IndonesiaDivision of Tropical and Infectious Disease, Internal Medicine Department, Faculty of Medicine Universitas IndonesiaAbstract Background Some anti-malarial drugs often cause haemolytic anaemia in glucose-6-phosphate-dehydrogenase deficiency (G6PDd) patients. This study aims to analyse the association of G6PDd and anaemia in malaria patients receiving anti-malarial drugs. Methods A literature search was performed in major database portals. All studies searched using keywords with Medical Subject Headings (MeSH) were included, without date or language restriction. Pooled mean difference of haemoglobin and risk ratio of anaemia were analysed using RevMan. Results Sixteen studies comprising 3474 malaria patients that included 398 (11.5%) with G6PDd were found. Mean difference of haemoglobin in G6PDd/G6PD normal (G6PDn) patients was − 0.16 g/dL (95% CI − 0.48, 0.15; I2 5%, p = 0.39), regardless of the type of malaria and dose of drugs. In particular with primaquine (PQ), mean difference of haemoglobin in G6PDd/G6PDn patients with dose < 0.5 mg/kg/day was − 0.04 (95% CI − 0.35, 0.27; I2 0%, p = 0.69). The risk ratio of developing anaemia in G6PDd patients was 1.02 (95% CI 0.75, 1.38; I2 0%, p = 0.79). Conclusion Single or daily standard doses of PQ (0.25 mg/kg/day) and weekly PQ (0.75 mg/kg/week) did not increase the risk of anaemia in G6PDd patients.https://doi.org/10.1186/s12936-023-04493-7AntimalarialG6PD deficiencyPrimaquineMalaria vivaxMalaria falciparum |
| spellingShingle | Erni J. Nelwan Sharifah Shakinah Adeline Pasaribu Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis Malaria Journal Antimalarial G6PD deficiency Primaquine Malaria vivax Malaria falciparum |
| title | Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis |
| title_full | Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis |
| title_fullStr | Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis |
| title_full_unstemmed | Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis |
| title_short | Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis |
| title_sort | association of g6pd status and haemolytic anaemia in patients receiving anti malarial agents a systematic review and meta analysis |
| topic | Antimalarial G6PD deficiency Primaquine Malaria vivax Malaria falciparum |
| url | https://doi.org/10.1186/s12936-023-04493-7 |
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