Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice
The timing of NAD + supply determines its efficacy to treat metabolic disease. Here, the authors show that increasing NAD + at the early active phase maximizes weight loss and glucose regulation in mice. NAD + can displace the phase of the liver clock which can cause circadian misalignment....
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Bibliographic Details
Main Authors: |
Quetzalcoatl Escalante-Covarrubias,
Lucía Mendoza-Viveros,
Mirna González-Suárez,
Román Sitten-Olea,
Laura A. Velázquez-Villegas,
Fernando Becerril-Pérez,
Ignacio Pacheco-Bernal,
Erick Carreño-Vázquez,
Paola Mass-Sánchez,
Marcia Bustamante-Zepeda,
Ricardo Orozco-Solís,
Lorena Aguilar-Arnal |
Format: | Article
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Language: | English |
Published: |
Nature Portfolio
2023-03-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-023-37286-2
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