Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice
The timing of NAD + supply determines its efficacy to treat metabolic disease. Here, the authors show that increasing NAD + at the early active phase maximizes weight loss and glucose regulation in mice. NAD + can displace the phase of the liver clock which can cause circadian misalignment....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37286-2 |
| _version_ | 1797853757477748736 |
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| author | Quetzalcoatl Escalante-Covarrubias Lucía Mendoza-Viveros Mirna González-Suárez Román Sitten-Olea Laura A. Velázquez-Villegas Fernando Becerril-Pérez Ignacio Pacheco-Bernal Erick Carreño-Vázquez Paola Mass-Sánchez Marcia Bustamante-Zepeda Ricardo Orozco-Solís Lorena Aguilar-Arnal |
| author_facet | Quetzalcoatl Escalante-Covarrubias Lucía Mendoza-Viveros Mirna González-Suárez Román Sitten-Olea Laura A. Velázquez-Villegas Fernando Becerril-Pérez Ignacio Pacheco-Bernal Erick Carreño-Vázquez Paola Mass-Sánchez Marcia Bustamante-Zepeda Ricardo Orozco-Solís Lorena Aguilar-Arnal |
| author_sort | Quetzalcoatl Escalante-Covarrubias |
| collection | DOAJ |
| description | The timing of NAD + supply determines its efficacy to treat metabolic disease. Here, the authors show that increasing NAD + at the early active phase maximizes weight loss and glucose regulation in mice. NAD + can displace the phase of the liver clock which can cause circadian misalignment. |
| first_indexed | 2024-04-09T19:54:49Z |
| format | Article |
| id | doaj.art-fbdcecb98964451ea63d43a530a1552e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T19:54:49Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fbdcecb98964451ea63d43a530a1552e2023-04-03T05:33:22ZengNature PortfolioNature Communications2041-17232023-03-0114112410.1038/s41467-023-37286-2Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in miceQuetzalcoatl Escalante-Covarrubias0Lucía Mendoza-Viveros1Mirna González-Suárez2Román Sitten-Olea3Laura A. Velázquez-Villegas4Fernando Becerril-Pérez5Ignacio Pacheco-Bernal6Erick Carreño-Vázquez7Paola Mass-Sánchez8Marcia Bustamante-Zepeda9Ricardo Orozco-Solís10Lorena Aguilar-Arnal11Departamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoLaboratorio de Cronobiología y Metabolismo, Instituto Nacional de Medicina GenómicaDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoLaboratorio de Cronobiología y Metabolismo, Instituto Nacional de Medicina GenómicaDepartamento de Biología Celular y Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoThe timing of NAD + supply determines its efficacy to treat metabolic disease. Here, the authors show that increasing NAD + at the early active phase maximizes weight loss and glucose regulation in mice. NAD + can displace the phase of the liver clock which can cause circadian misalignment.https://doi.org/10.1038/s41467-023-37286-2 |
| spellingShingle | Quetzalcoatl Escalante-Covarrubias Lucía Mendoza-Viveros Mirna González-Suárez Román Sitten-Olea Laura A. Velázquez-Villegas Fernando Becerril-Pérez Ignacio Pacheco-Bernal Erick Carreño-Vázquez Paola Mass-Sánchez Marcia Bustamante-Zepeda Ricardo Orozco-Solís Lorena Aguilar-Arnal Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice Nature Communications |
| title | Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice |
| title_full | Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice |
| title_fullStr | Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice |
| title_full_unstemmed | Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice |
| title_short | Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice |
| title_sort | time of day defines nad efficacy to treat diet induced metabolic disease by synchronizing the hepatic clock in mice |
| url | https://doi.org/10.1038/s41467-023-37286-2 |
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