Induction and maintenance of bi-functional (IFN-γ + IL-2+ and IL-2+ TNF-α+) T cell responses by DNA prime MVA boosted subtype C prophylactic vaccine tested in a Phase I trial in India.

Induction and maintenance of bi-functional (IFN-γ + IL-2+ and IL-2+ TNF-α+) T cell responses by DNA prime MVA boosted subtype C prophylactic vaccine tested in a Phase I trial in India.

Effective vaccine design relies on accurate knowledge of protection against a pathogen, so as to be able to induce relevant and effective protective responses against it. An ideal Human Immunodeficiency virus (HIV) vaccine should induce humoral as well as cellular immune responses to prevent initial...

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Bibliographic Details
Main Authors: Sivasankaran Munusamy Ponnan, Sathyamurthy Pattabiram, Kannan Thiruvengadam, Rajat Goyal, Nikhil Singla, Joyeeta Mukherjee, Shweta Chatrath, Philip Bergin, Jakub T Kopycinski, Jill Gilmour, Sriram Kumar, Malathy Muthu, Sudha Subramaniam, Soumya Swaminathan, Srikanth Prasad Tripathy, Hanna Elizabeth Luke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213911

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