Hypoxia Induces Autophagy of Bone Marrow-Derived Mesenchymal Stem Cells via Activation of ERK1/2

Hypoxia Induces Autophagy of Bone Marrow-Derived Mesenchymal Stem Cells via Activation of ERK1/2

Background: Bone marrow-derived mesenchymal stem cells (bmMSCs) are the most promising seed cells for cell transplant therapy. Hypoxia is a known stimulus of autophagy. Recent studies showed that hypoxia promotes autophagy of human placental chorionic plate-derived mesenchymal stem cells (CP-MSCs)....

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Bibliographic Details
Main Authors: Junfang Wu, Jie Niu, Xiaopeng Li, Yonghai Li, Xianwei Wang, Juntang Lin, Fenxi Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hypoxia
Bone marrow derived mesenchymal stem cells
Extracellular signal-regulated kinase 1/2 (ERK1/2)
Autophagy
Online Access:http://www.karger.com/Article/FullText/358711

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