Drug repurposing based on the similarity gene expression signatures to explore for potential indications of quercetin: a case study of multiple sclerosis

Drug repurposing based on the similarity gene expression signatures to explore for potential indications of quercetin: a case study of multiple sclerosis

Quercetin (QR) is a natural flavonol compound widely distributed in the plant kingdom with extensive pharmacological effects. To find the potential clinical indications of QR, 156 differentially expressed genes (DEGs) regulated by QR were obtained from the Gene Expression Omnibus database, and new p...

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Bibliographic Details
Main Authors: Yulong Chen, Mingliang Zhang, Weixia Li, Xiaoyan Wang, Xiaofei Chen, Yali Wu, Hui Zhang, Liuqing Yang, Bing Han, Jinfa Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Chemistry
Subjects:
natural products
drug repurposing
drug discovery
quercetin
multiple sclerosis
medicinal indications
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1250043/full

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