Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
Khaled Alzahrani,1,2 Syarifah-Faiza Dardin,1 Fiona Carley,2 Arun Brahma,2 Debbie Morley,2 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-03-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/corneal-clarity-measurements-in-patients-with-keratoconus-undergoing-e-peer-reviewed-article-OPTH |
| _version_ | 1818852165512331264 |
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| author | Alzahrani K Dardin SF Carley F Brahma A Morley D Hillarby MC |
| author_facet | Alzahrani K Dardin SF Carley F Brahma A Morley D Hillarby MC |
| author_sort | Alzahrani K |
| collection | DOAJ |
| description | Khaled Alzahrani,1,2 Syarifah-Faiza Dardin,1 Fiona Carley,2 Arun Brahma,2 Debbie Morley,2 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK Purpose: To compare the corneal clarity measurement between penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) in patients with keratoconus, using densitometry software for the Oculus Pentacam.Methods: A retrospective comparative study was carried out at Manchester Royal Eye Hospital. Data were collected 12–18 months after corneal transplantation for keratoconus, including postoperative corneal densitometry, best corrected visual acuity (BCVA), central corneal thickness (CCT), and other relevant clinical details.Results: Analysis of 37 keratoconus eyes from 36 patients found there was a significantly higher corneal densitometry measurement after DALK than PK. This was predominantly in the posterior layer of the concentric zone 0–2 mm of the cornea (P=0.0004). A significant correlation was found between postoperative BCVA and corneal densitometry in DALK groups at full thickness (P=0.03). This correlation was seen in the central 0–2 mm (P=0.03) and posterior 0–2 mm (P=0.04) zones. In addition, within the DALK group, a correlation was found between central corneal thickness and densitometry at full thickness 2–6 mm (P=0.007), central 0–2 (P=0.04), central 2–6 mm (P=0.01), and at posterior 2–6 mm (P=0.01) zones.Conclusion: This study showed that corneal densitometry measurement differs depending on the type of corneal transplantation used to treat keratoconus patients. Densitometry may have an important role to play in the final BCVA achieved by patients undergoing corneal transplantation for keratoconus. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the cornea status after the surgery. Keywords: keratocytes, corneal transplantation, corneal wound healing, keratoconus, transparency |
| first_indexed | 2024-12-19T07:16:35Z |
| format | Article |
| id | doaj.art-fbe247d412b74a5e977082d562693a04 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T07:16:35Z |
| publishDate | 2018-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-fbe247d412b74a5e977082d562693a042022-12-21T20:31:03ZengDove Medical PressClinical Ophthalmology1177-54832018-03-01Volume 1257758537397Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplastyAlzahrani KDardin SFCarley FBrahma AMorley DHillarby MCKhaled Alzahrani,1,2 Syarifah-Faiza Dardin,1 Fiona Carley,2 Arun Brahma,2 Debbie Morley,2 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK Purpose: To compare the corneal clarity measurement between penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) in patients with keratoconus, using densitometry software for the Oculus Pentacam.Methods: A retrospective comparative study was carried out at Manchester Royal Eye Hospital. Data were collected 12–18 months after corneal transplantation for keratoconus, including postoperative corneal densitometry, best corrected visual acuity (BCVA), central corneal thickness (CCT), and other relevant clinical details.Results: Analysis of 37 keratoconus eyes from 36 patients found there was a significantly higher corneal densitometry measurement after DALK than PK. This was predominantly in the posterior layer of the concentric zone 0–2 mm of the cornea (P=0.0004). A significant correlation was found between postoperative BCVA and corneal densitometry in DALK groups at full thickness (P=0.03). This correlation was seen in the central 0–2 mm (P=0.03) and posterior 0–2 mm (P=0.04) zones. In addition, within the DALK group, a correlation was found between central corneal thickness and densitometry at full thickness 2–6 mm (P=0.007), central 0–2 (P=0.04), central 2–6 mm (P=0.01), and at posterior 2–6 mm (P=0.01) zones.Conclusion: This study showed that corneal densitometry measurement differs depending on the type of corneal transplantation used to treat keratoconus patients. Densitometry may have an important role to play in the final BCVA achieved by patients undergoing corneal transplantation for keratoconus. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the cornea status after the surgery. Keywords: keratocytes, corneal transplantation, corneal wound healing, keratoconus, transparencyhttps://www.dovepress.com/corneal-clarity-measurements-in-patients-with-keratoconus-undergoing-e-peer-reviewed-article-OPTHkeratocytescorneal transplantationcorneal wound healingkeratoconustransparency |
| spellingShingle | Alzahrani K Dardin SF Carley F Brahma A Morley D Hillarby MC Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty Clinical Ophthalmology keratocytes corneal transplantation corneal wound healing keratoconus transparency |
| title | Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty |
| title_full | Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty |
| title_fullStr | Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty |
| title_full_unstemmed | Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty |
| title_short | Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty |
| title_sort | corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty |
| topic | keratocytes corneal transplantation corneal wound healing keratoconus transparency |
| url | https://www.dovepress.com/corneal-clarity-measurements-in-patients-with-keratoconus-undergoing-e-peer-reviewed-article-OPTH |
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