Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery
To evaluate the degradation behavior of theophylline/chitosan/?-cyclo-dextrin microspheres, we performed both in vitro study by putting the microspheres in phosphate buffered saline or in phosphate buffer saline with enzyme and in vivo study by implanting the microspheres into the back of male Sprag...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2016-03-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/25634 |
| _version_ | 1828469697373274112 |
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| author | Li Wang Tingting Yang Weiping Ju Ming Ren Zhanqin Feng Zengjuan Zheng Zhenbo Hu Yuqing Liu Weifen Zhang |
| author_facet | Li Wang Tingting Yang Weiping Ju Ming Ren Zhanqin Feng Zengjuan Zheng Zhenbo Hu Yuqing Liu Weifen Zhang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | To evaluate the degradation behavior of theophylline/chitosan/?-cyclo-dextrin microspheres, we performed both in vitro study by putting the microspheres in phosphate buffered saline or in phosphate buffer saline with enzyme and in vivo study by implanting the microspheres into the back of male Sprague-Dawley rats. The results showed that microspheres were degraded in enzymatic hydrolysis and phosphate buffer saline, which were degraded faster in 0.2 mg/mL lysozyme than in phosphate buffer saline. The morphology of microspheres in phosphate buffer saline and enzyme solution developed rough surfaces, and showed irregular shape and pores after 8 weeks. The microspheres were degraded in vivo within 8 weeks with irregular, sheet, porous morphology, and the diameters were smaller than 5 ?m. These results indicated that the theophylline/chitosan/?-cyclodextrin microspheres had a good degradation both in vitro and in vivo which can be used as a pulmonary drug delivery carrier. |
| first_indexed | 2024-12-11T04:42:50Z |
| format | Article |
| id | doaj.art-fbe3100cfea341af9e420ae9798045e3 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-11T04:42:50Z |
| publishDate | 2016-03-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-fbe3100cfea341af9e420ae9798045e32022-12-22T01:20:35ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-03-0111S1Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug deliveryLi Wang0Tingting Yang1Weiping Ju2Ming Ren3Zhanqin Feng4Zengjuan Zheng5Zhenbo Hu6Yuqing Liu7Weifen Zhang8Affiliated Reproductive Medicine Center, Weifang Medical University, Weifang 261042, ShandongDepartment of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053Department of Neurology, Wendeng Central Hospital of Weihai, Affiliated Hospital of Weifang Medical University, Wendeng 266400, ShandongAffiliated Hospital of Weifang Medical University, Weifang 261053Department of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053Department of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053Affiliated Hospital of Weifang Medical University, Weifang 261053Department of Pathology, College of Basic Medicine, Weifang Medical University, Weifang 261053Department of Pharmaceutics, College of Pharmacy, Weifang Medical University, Weifang 261053To evaluate the degradation behavior of theophylline/chitosan/?-cyclo-dextrin microspheres, we performed both in vitro study by putting the microspheres in phosphate buffered saline or in phosphate buffer saline with enzyme and in vivo study by implanting the microspheres into the back of male Sprague-Dawley rats. The results showed that microspheres were degraded in enzymatic hydrolysis and phosphate buffer saline, which were degraded faster in 0.2 mg/mL lysozyme than in phosphate buffer saline. The morphology of microspheres in phosphate buffer saline and enzyme solution developed rough surfaces, and showed irregular shape and pores after 8 weeks. The microspheres were degraded in vivo within 8 weeks with irregular, sheet, porous morphology, and the diameters were smaller than 5 ?m. These results indicated that the theophylline/chitosan/?-cyclodextrin microspheres had a good degradation both in vitro and in vivo which can be used as a pulmonary drug delivery carrier.https://www.banglajol.info/index.php/BJP/article/view/25634Chitosan?-CyclodextrinPulmonary drug deliveryTheophylline |
| spellingShingle | Li Wang Tingting Yang Weiping Ju Ming Ren Zhanqin Feng Zengjuan Zheng Zhenbo Hu Yuqing Liu Weifen Zhang Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery Bangladesh Journal of Pharmacology Chitosan ?-Cyclodextrin Pulmonary drug delivery Theophylline |
| title | Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery |
| title_full | Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery |
| title_fullStr | Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery |
| title_full_unstemmed | Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery |
| title_short | Degradation behavior of theophylline/chitosan/?-cyclodextrin microspheres for pulmonary drug delivery |
| title_sort | degradation behavior of theophylline chitosan cyclodextrin microspheres for pulmonary drug delivery |
| topic | Chitosan ?-Cyclodextrin Pulmonary drug delivery Theophylline |
| url | https://www.banglajol.info/index.php/BJP/article/view/25634 |
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