An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing Radiation
The biological effects of ionizing radiation on organisms have emerged as a hot topic for research. In this study, the changes of metabolic profile in the kidney tissues extracts from C57BL/6J mice with or without exposing to whole body gamma or proton radiation were investigated with the liquid sta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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Science Press
2019-06-01
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| Series: | Chinese Journal of Magnetic Resonance |
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| Online Access: | http://html.rhhz.net/bpxzz/html/20190206.htm |
| _version_ | 1818311730765234176 |
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| author | XIAO Xiong-jie HU Mary ZHANG Xu HU Jian-zhi |
| author_facet | XIAO Xiong-jie HU Mary ZHANG Xu HU Jian-zhi |
| author_sort | XIAO Xiong-jie |
| collection | DOAJ |
| description | The biological effects of ionizing radiation on organisms have emerged as a hot topic for research. In this study, the changes of metabolic profile in the kidney tissues extracts from C57BL/6J mice with or without exposing to whole body gamma or proton radiation were investigated with the liquid state proton nuclear magnetic resonance (1H NMR)-based metabolomics approach. The results demonstrated that the exposed group had significantly different kidney metabolic profiles from the non-exposed group, involving mainly six metabolites, including 2-aminobutyrate, 3-hydroxybutyrate, homoserine, 1,3-diaminopropane, β-alanine and ascorbate. These metabolites could be used as potential biomarkers for the biological effects of high-dose ionizing radiation on kidney metabolism. |
| first_indexed | 2024-12-13T08:06:36Z |
| format | Article |
| id | doaj.art-fbe475a1d0154d42aaaab910d35fdb4e |
| institution | Directory Open Access Journal |
| issn | 1000-4556 1000-4556 |
| language | zho |
| last_indexed | 2024-12-13T08:06:36Z |
| publishDate | 2019-06-01 |
| publisher | Science Press |
| record_format | Article |
| series | Chinese Journal of Magnetic Resonance |
| spelling | doaj.art-fbe475a1d0154d42aaaab910d35fdb4e2022-12-21T23:54:18ZzhoScience PressChinese Journal of Magnetic Resonance1000-45561000-45562019-06-0136217218110.11938/cjmr20182622An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing RadiationXIAO Xiong-jie0HU Mary1ZHANG Xu2HU Jian-zhi31. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China; 3. Pacific Northwest National Laboratory, Richland, WA 99352, USAPacific Northwest National Laboratory, Richland, WA 99352, USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, ChinaPacific Northwest National Laboratory, Richland, WA 99352, USAThe biological effects of ionizing radiation on organisms have emerged as a hot topic for research. In this study, the changes of metabolic profile in the kidney tissues extracts from C57BL/6J mice with or without exposing to whole body gamma or proton radiation were investigated with the liquid state proton nuclear magnetic resonance (1H NMR)-based metabolomics approach. The results demonstrated that the exposed group had significantly different kidney metabolic profiles from the non-exposed group, involving mainly six metabolites, including 2-aminobutyrate, 3-hydroxybutyrate, homoserine, 1,3-diaminopropane, β-alanine and ascorbate. These metabolites could be used as potential biomarkers for the biological effects of high-dose ionizing radiation on kidney metabolism.http://html.rhhz.net/bpxzz/html/20190206.htmproton nuclear magnetic resonance (1H NMR)metabolomicsionizing radiationkidneymultivariate data analysis |
| spellingShingle | XIAO Xiong-jie HU Mary ZHANG Xu HU Jian-zhi An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing Radiation Chinese Journal of Magnetic Resonance proton nuclear magnetic resonance (1H NMR) metabolomics ionizing radiation kidney multivariate data analysis |
| title | An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing Radiation |
| title_full | An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing Radiation |
| title_fullStr | An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing Radiation |
| title_full_unstemmed | An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing Radiation |
| title_short | An NMR-Based Metabolomics Study of Kidneys from Mice Exposed to Ionizing Radiation |
| title_sort | nmr based metabolomics study of kidneys from mice exposed to ionizing radiation |
| topic | proton nuclear magnetic resonance (1H NMR) metabolomics ionizing radiation kidney multivariate data analysis |
| url | http://html.rhhz.net/bpxzz/html/20190206.htm |
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