Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells

Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8+ T Cells

We investigated the influence of a transient treatment of corticosteroid on CD8+ T cells during herpesvirus infection. Dexamethasone, a synthetic corticosteroid, induced apoptosis of naïve and memory CD8+ T cells but virus-specific effector cells were spared. CD8+ T cell susceptibility was directly...

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Bibliographic Details
Main Authors:	Dhaneshwar Kumar, Sharvan Sehrawat
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Series:	Frontiers in Immunology
Subjects:	CD8+ T cells virus immunology immunosuppresants memory differentiation
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01521/full

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