Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology

Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology

Summary: Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association studies (GWASs), PRSmulti, hold promise for improving PRS accuracy and generalizability across populations. To establish best practices for leveraging the increasing diversity of genomic studies, we investiga...

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Bibliographic Details
Main Authors: Ying Wang, Masahiro Kanai, Taotao Tan, Mireille Kamariza, Kristin Tsuo, Kai Yuan, Wei Zhou, Yukinori Okada, Hailiang Huang, Patrick Turley, Elizabeth G. Atkinson, Alicia R. Martin
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Genomics
Subjects:
genome-wide association studies
multi-ancestry
polygenic risk scores
genetic architecture
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X23002227

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http://www.sciencedirect.com/science/article/pii/S2666979X23002227

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