The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study
Electrochemotherapy (ECT) is a treatment involving the administration of chemotherapeutics drugs followed by the application of 8 square monopolar pulses of 100 μs duration at a repetition frequency of 1 Hz or 5000 Hz. However, there is increasing interest in using alternative types of pulses for EC...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2024-02-01
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| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2024-0005 |
| _version_ | 1827341051136835584 |
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| author | Scuderi Maria Dermol-Cerne Janja Scancar Janez Markovic Stefan Rems Lea Miklavcic Damijan |
| author_facet | Scuderi Maria Dermol-Cerne Janja Scancar Janez Markovic Stefan Rems Lea Miklavcic Damijan |
| author_sort | Scuderi Maria |
| collection | DOAJ |
| description | Electrochemotherapy (ECT) is a treatment involving the administration of chemotherapeutics drugs followed by the application of 8 square monopolar pulses of 100 μs duration at a repetition frequency of 1 Hz or 5000 Hz. However, there is increasing interest in using alternative types of pulses for ECT. The use of high-frequency short bipolar pulses has been shown to mitigate pain and muscle contractions. Conversely, the use of millisecond pulses is interesting when combining ECT with gene electrotransfer for the uptake of DNA-encoding proteins that stimulate the immune response with the aim of converting ECT from a local to systemic treatment. Therefore, the aim of this study was to investigate how alternative types of pulses affect the efficiency of the ECT. |
| first_indexed | 2024-03-07T21:34:14Z |
| format | Article |
| id | doaj.art-fbec876757404018a6bc5502c1548569 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-03-07T21:34:14Z |
| publishDate | 2024-02-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-fbec876757404018a6bc5502c15485692024-02-26T14:30:09ZengSciendoRadiology and Oncology1581-32072024-02-01581516610.2478/raon-2024-0005The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro studyScuderi Maria0Dermol-Cerne Janja1Scancar Janez2Markovic Stefan3Rems Lea4Miklavcic Damijan5Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, SloveniaFaculty of Electrical Engineering, University of Ljubljana, Ljubljana, SloveniaDepartment of Environmental Sciences, Jožef Stefan Institute, Ljubljana, SloveniaDepartment of Environmental Sciences, Jožef Stefan Institute, Ljubljana, SloveniaFaculty of Electrical Engineering, University of Ljubljana, Ljubljana, SloveniaFaculty of Electrical Engineering, University of Ljubljana, Ljubljana, SloveniaElectrochemotherapy (ECT) is a treatment involving the administration of chemotherapeutics drugs followed by the application of 8 square monopolar pulses of 100 μs duration at a repetition frequency of 1 Hz or 5000 Hz. However, there is increasing interest in using alternative types of pulses for ECT. The use of high-frequency short bipolar pulses has been shown to mitigate pain and muscle contractions. Conversely, the use of millisecond pulses is interesting when combining ECT with gene electrotransfer for the uptake of DNA-encoding proteins that stimulate the immune response with the aim of converting ECT from a local to systemic treatment. Therefore, the aim of this study was to investigate how alternative types of pulses affect the efficiency of the ECT.https://doi.org/10.2478/raon-2024-0005electrochemotherapyelectroporationcisplatin uptakephenomenological modelequivalent pulse parameters |
| spellingShingle | Scuderi Maria Dermol-Cerne Janja Scancar Janez Markovic Stefan Rems Lea Miklavcic Damijan The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study Radiology and Oncology electrochemotherapy electroporation cisplatin uptake phenomenological model equivalent pulse parameters |
| title | The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study |
| title_full | The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study |
| title_fullStr | The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study |
| title_full_unstemmed | The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study |
| title_short | The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study |
| title_sort | equivalence of different types of electric pulses for electrochemotherapy with cisplatin an in vitro study |
| topic | electrochemotherapy electroporation cisplatin uptake phenomenological model equivalent pulse parameters |
| url | https://doi.org/10.2478/raon-2024-0005 |
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