COVID-19 in pediatrics: Genetic susceptibility
The uptick in SARS-CoV-2 infection has resulted in a worldwide COVID-19 pandemic, which has created troublesome health and economic problems. We performed case–control meta-analyses in both African and European ethnicity COVID-19 disease cases based on laboratory test and phenotypic criteria. The ca...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.928466/full |
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| author | Joseph T. Glessner Joseph T. Glessner Xiao Chang Frank Mentch Huiqi Qu Debra J. Abrams Alexandria Thomas Patrick M. A. Sleiman Patrick M. A. Sleiman Hakon Hakonarson Hakon Hakonarson |
| author_facet | Joseph T. Glessner Joseph T. Glessner Xiao Chang Frank Mentch Huiqi Qu Debra J. Abrams Alexandria Thomas Patrick M. A. Sleiman Patrick M. A. Sleiman Hakon Hakonarson Hakon Hakonarson |
| author_sort | Joseph T. Glessner |
| collection | DOAJ |
| description | The uptick in SARS-CoV-2 infection has resulted in a worldwide COVID-19 pandemic, which has created troublesome health and economic problems. We performed case–control meta-analyses in both African and European ethnicity COVID-19 disease cases based on laboratory test and phenotypic criteria. The cases had laboratory-confirmed SARS-CoV-2 infection. We uniquely investigated COVID infection genetics in a pediatric population. Our cohort has a large African ancestry component, also unique to our study. We tested for genetic variant association in 498 cases vs. 1,533 controls of African ancestry and 271 cases vs. 855 controls of European ancestry. We acknowledge that the sample size is relatively small, owing to the low prevalence of COVID infection among pediatric individuals. COVID-19 cases averaged 13 years of age. Pediatric genetic studies enhance the ability to detect genetic associations with a limited possible environment impact. Our findings support the notion that some genetic variants, most notably at the SEMA6D, FMN1, ACTN1, PDS5B, NFIA, ADGRL3, MMP27, TENM3, SPRY4, MNS1, and RSU1 loci, play a role in COVID-19 infection susceptibility. The pediatric cohort also shows nominal replication of previously reported adult study results: CCR9, CXCR6, FYCO1, LZTFL1, TDGF1, CCR1, CCR2, CCR3, CCR5, MAPT-AS1, and IFNAR2 gene variants. Reviewing the biological roles of genes implicated here, NFIA looks to be the most interesting as it binds to a palindromic sequence observed in both viral and cellular promoters and in the adenovirus type 2 origin of replication. |
| first_indexed | 2024-04-13T13:14:41Z |
| format | Article |
| id | doaj.art-fbedbec0145e41e48a172bf285429031 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T13:14:41Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-fbedbec0145e41e48a172bf2854290312022-12-22T02:45:31ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.928466928466COVID-19 in pediatrics: Genetic susceptibilityJoseph T. Glessner0Joseph T. Glessner1Xiao Chang2Frank Mentch3Huiqi Qu4Debra J. Abrams5Alexandria Thomas6Patrick M. A. Sleiman7Patrick M. A. Sleiman8Hakon Hakonarson9Hakon Hakonarson10Children’s Hospital of Philadelphia, Philadelphia, PA, United StatesPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesChildren’s Hospital of Philadelphia, Philadelphia, PA, United StatesChildren’s Hospital of Philadelphia, Philadelphia, PA, United StatesChildren’s Hospital of Philadelphia, Philadelphia, PA, United StatesChildren’s Hospital of Philadelphia, Philadelphia, PA, United StatesChildren’s Hospital of Philadelphia, Philadelphia, PA, United StatesChildren’s Hospital of Philadelphia, Philadelphia, PA, United StatesPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesChildren’s Hospital of Philadelphia, Philadelphia, PA, United StatesPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United StatesThe uptick in SARS-CoV-2 infection has resulted in a worldwide COVID-19 pandemic, which has created troublesome health and economic problems. We performed case–control meta-analyses in both African and European ethnicity COVID-19 disease cases based on laboratory test and phenotypic criteria. The cases had laboratory-confirmed SARS-CoV-2 infection. We uniquely investigated COVID infection genetics in a pediatric population. Our cohort has a large African ancestry component, also unique to our study. We tested for genetic variant association in 498 cases vs. 1,533 controls of African ancestry and 271 cases vs. 855 controls of European ancestry. We acknowledge that the sample size is relatively small, owing to the low prevalence of COVID infection among pediatric individuals. COVID-19 cases averaged 13 years of age. Pediatric genetic studies enhance the ability to detect genetic associations with a limited possible environment impact. Our findings support the notion that some genetic variants, most notably at the SEMA6D, FMN1, ACTN1, PDS5B, NFIA, ADGRL3, MMP27, TENM3, SPRY4, MNS1, and RSU1 loci, play a role in COVID-19 infection susceptibility. The pediatric cohort also shows nominal replication of previously reported adult study results: CCR9, CXCR6, FYCO1, LZTFL1, TDGF1, CCR1, CCR2, CCR3, CCR5, MAPT-AS1, and IFNAR2 gene variants. Reviewing the biological roles of genes implicated here, NFIA looks to be the most interesting as it binds to a palindromic sequence observed in both viral and cellular promoters and in the adenovirus type 2 origin of replication.https://www.frontiersin.org/articles/10.3389/fgene.2022.928466/fullGWASgenome-wide association studydiverse populationspediatricsstatistical genetics and genomicsCOVID-19 |
| spellingShingle | Joseph T. Glessner Joseph T. Glessner Xiao Chang Frank Mentch Huiqi Qu Debra J. Abrams Alexandria Thomas Patrick M. A. Sleiman Patrick M. A. Sleiman Hakon Hakonarson Hakon Hakonarson COVID-19 in pediatrics: Genetic susceptibility Frontiers in Genetics GWAS genome-wide association study diverse populations pediatrics statistical genetics and genomics COVID-19 |
| title | COVID-19 in pediatrics: Genetic susceptibility |
| title_full | COVID-19 in pediatrics: Genetic susceptibility |
| title_fullStr | COVID-19 in pediatrics: Genetic susceptibility |
| title_full_unstemmed | COVID-19 in pediatrics: Genetic susceptibility |
| title_short | COVID-19 in pediatrics: Genetic susceptibility |
| title_sort | covid 19 in pediatrics genetic susceptibility |
| topic | GWAS genome-wide association study diverse populations pediatrics statistical genetics and genomics COVID-19 |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.928466/full |
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