Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning
Background and Aim: Aluminum phosphide poisoning has a high mortality rate because of the production of phosphine gas and refractory hypotension. Based on the effect of dihydroxyacetone on the treatment of hypotension and reduction of cytochrome C oxidase, the effects of dihydroxyacetone on the leve...
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| Format: | Article |
| Language: | fas |
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Kurdistan University of Medical Sciences
2023-03-01
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| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Subjects: | |
| Online Access: | http://sjku.muk.ac.ir/article-1-6812-en.html |
| _version_ | 1797834636187926528 |
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| author | jafar ahmadi Elham Jafari Mahmoud Reza Heidari Mahsa Eskandari Fatemeh Yousefi Somayeh Karami Mohajeri |
| author_facet | jafar ahmadi Elham Jafari Mahmoud Reza Heidari Mahsa Eskandari Fatemeh Yousefi Somayeh Karami Mohajeri |
| author_sort | jafar ahmadi |
| collection | DOAJ |
| description | Background and Aim: Aluminum phosphide poisoning has a high mortality rate because of the production of phosphine gas and refractory hypotension. Based on the effect of dihydroxyacetone on the treatment of hypotension and reduction of cytochrome C oxidase, the effects of dihydroxyacetone on the level of oxidative stress factors and histology of heart and liver tissue in aluminum phosphide-poisoned male rats were investigated.
Materials and Methods: In this study, 24 rats were randomly divided into 4 groups including control (corn oil), aluminum phosphide (15 mg/kg), dihydroxyacetone (50 mg/kg) and also poisoned and treated group (aluminum phosphide (15 mg/kg) + dihydroxyacetone (50 mg/kg)). After 24 hours, the animals were sacrificed and the blood, plasma, heart, and liver samples were collected then oxidative stress factors and histology of the heart and liver were investigated.
Results: Aluminum phosphide poisoning increased lipid peroxidation in red blood cells (p=0.001) and liver tissue (p=0.023) and also increased protein carbonylation in plasma (p =0.005) and red blood cells (p=0.001). After administration of dihydroxyacetone, lipid peroxidation in red blood cells (p=0.001) and liver (p=0.001) and carbonylation of proteins in red blood cells (p=0.003) and plasma (p=0.019) decreased. No significant change was observed in total plasma antioxidant capacity, carbonylation levels of the liver and heart, and lipid peroxidation in heart tissue. In addition, treatment with dihydroxyacetone significantly improved the histological changes in liver and heart tissue.
Conclusion: Dihydroxyacetone not only prevents phosphine-induced deaths but also improves oxidative stress and histology of liver and heart tissue. |
| first_indexed | 2024-04-09T14:40:47Z |
| format | Article |
| id | doaj.art-fbee70f2f6c64da7a5405456ff5979d5 |
| institution | Directory Open Access Journal |
| issn | 1560-652X 2345-4040 |
| language | fas |
| last_indexed | 2024-04-09T14:40:47Z |
| publishDate | 2023-03-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj.art-fbee70f2f6c64da7a5405456ff5979d52023-05-03T08:14:41ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402023-03-012814054Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoningjafar ahmadi0Elham Jafari1Mahmoud Reza Heidari2Mahsa Eskandari3Fatemeh Yousefi4Somayeh Karami Mohajeri5 Pharmaceutics Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Associate Professor, Department of Pathology, Pathology and Stem Cells Research Center, Kerman University of Medical Science, Kerman, Iran Professor, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran. Assistant Professor, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Background and Aim: Aluminum phosphide poisoning has a high mortality rate because of the production of phosphine gas and refractory hypotension. Based on the effect of dihydroxyacetone on the treatment of hypotension and reduction of cytochrome C oxidase, the effects of dihydroxyacetone on the level of oxidative stress factors and histology of heart and liver tissue in aluminum phosphide-poisoned male rats were investigated. Materials and Methods: In this study, 24 rats were randomly divided into 4 groups including control (corn oil), aluminum phosphide (15 mg/kg), dihydroxyacetone (50 mg/kg) and also poisoned and treated group (aluminum phosphide (15 mg/kg) + dihydroxyacetone (50 mg/kg)). After 24 hours, the animals were sacrificed and the blood, plasma, heart, and liver samples were collected then oxidative stress factors and histology of the heart and liver were investigated. Results: Aluminum phosphide poisoning increased lipid peroxidation in red blood cells (p=0.001) and liver tissue (p=0.023) and also increased protein carbonylation in plasma (p =0.005) and red blood cells (p=0.001). After administration of dihydroxyacetone, lipid peroxidation in red blood cells (p=0.001) and liver (p=0.001) and carbonylation of proteins in red blood cells (p=0.003) and plasma (p=0.019) decreased. No significant change was observed in total plasma antioxidant capacity, carbonylation levels of the liver and heart, and lipid peroxidation in heart tissue. In addition, treatment with dihydroxyacetone significantly improved the histological changes in liver and heart tissue. Conclusion: Dihydroxyacetone not only prevents phosphine-induced deaths but also improves oxidative stress and histology of liver and heart tissue.http://sjku.muk.ac.ir/article-1-6812-en.htmlrice tablephosphinefumigantcytochrome c oxidasedihydroxyacetone |
| spellingShingle | jafar ahmadi Elham Jafari Mahmoud Reza Heidari Mahsa Eskandari Fatemeh Yousefi Somayeh Karami Mohajeri Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning مجله علمی دانشگاه علوم پزشکی کردستان rice table phosphine fumigant cytochrome c oxidase dihydroxyacetone |
| title | Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning |
| title_full | Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning |
| title_fullStr | Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning |
| title_full_unstemmed | Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning |
| title_short | Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning |
| title_sort | investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning |
| topic | rice table phosphine fumigant cytochrome c oxidase dihydroxyacetone |
| url | http://sjku.muk.ac.ir/article-1-6812-en.html |
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