Improved Stability of a Stable Crystal Form C of 6S-5-Methyltetrahydrofolate Calcium Salt, Method Development and Validation of an LC–MS/MS Method for Rat Pharmacokinetic Comparison

Improved Stability of a Stable Crystal Form C of 6S-5-Methyltetrahydrofolate Calcium Salt, Method Development and Validation of an LC–MS/MS Method for Rat Pharmacokinetic Comparison

Folate is a vitamin beneficial for humans that plays an important role in metabolism, but it cannot be well supplemented by food; it is necessary to supplement it in other ways. Based on this consideration, a novel crystal form C of 6S-5-methyltetrahydrofolate calcium salt (MTHF CAC) was obtained. T...

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Bibliographic Details
Main Authors: Zenglin Lian, Hong Chen, Kang Liu, Qianghua Jia, Feng Qiu, Yongzhi Cheng
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
6S-5-methyltetrahydrofolate
crystal form C
stability
pharmacokinetics
LC–MS/MS
Online Access:https://www.mdpi.com/1420-3049/26/19/6011

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