Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report
A four-year-old Bullmastiff weighing 44 kg was presented with a 14-day history of weight loss, vomiting and diarrhoea. Abdominal ultrasonography showed the presence of abdominal lymphadenopathy and thickening of the wall of the descending colon. Esophagogastroduodenoscopy and colonoscopy with biopsy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2018-01-01
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| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201801-0007_gastrointestinal-b-lymphoblastic-lymphoma-in-a-dog-a-case-report.php |
| _version_ | 1797897557557379072 |
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| author | P. Borska R. Husnik P. Fictum A. Kehl L. Leva M. Faldyna |
| author_facet | P. Borska R. Husnik P. Fictum A. Kehl L. Leva M. Faldyna |
| author_sort | P. Borska |
| collection | DOAJ |
| description | A four-year-old Bullmastiff weighing 44 kg was presented with a 14-day history of weight loss, vomiting and diarrhoea. Abdominal ultrasonography showed the presence of abdominal lymphadenopathy and thickening of the wall of the descending colon. Esophagogastroduodenoscopy and colonoscopy with biopsy were performed. Histological examination revealed a high-grade lymphoblastic lymphoma, flow cytometric analysis detected malignant cells of the immature B phenotype. PCR for antigen receptor rearrangement confirmed IgH monoclonality pointing together with immunophenotyping to B-cell lymphoma. The dog was treated using a multi-agent chemotherapy protocol. The overall survival time was 487 days. This was an unusual case of primary gastrointestinal B-lymphoblastic lymphoma in a dog with survival equivalent to that of the multicentric form. |
| first_indexed | 2024-04-10T07:59:13Z |
| format | Article |
| id | doaj.art-fbeee349fb3c4a8ea69c327027d8eca4 |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T07:59:13Z |
| publishDate | 2018-01-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-fbeee349fb3c4a8ea69c327027d8eca42023-02-23T03:50:46ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922018-01-01631404910.17221/114/2017-VETMEDvet-201801-0007Gastrointestinal B-lymphoblastic lymphoma in a dog: a case reportP. Borska0R. Husnik1P. Fictum2A. Kehl3L. Leva4M. Faldyna5University of Veterinary and Pharmaceutical Sciences, Brno, Czech RepublicLouisiana State University, Louisiana, USAUniversity of Veterinary and Pharmaceutical Sciences, Brno, Czech RepublicLaboklin, GermanyVeterinary Research Institute, Brno, Czech RepublicVeterinary Research Institute, Brno, Czech RepublicA four-year-old Bullmastiff weighing 44 kg was presented with a 14-day history of weight loss, vomiting and diarrhoea. Abdominal ultrasonography showed the presence of abdominal lymphadenopathy and thickening of the wall of the descending colon. Esophagogastroduodenoscopy and colonoscopy with biopsy were performed. Histological examination revealed a high-grade lymphoblastic lymphoma, flow cytometric analysis detected malignant cells of the immature B phenotype. PCR for antigen receptor rearrangement confirmed IgH monoclonality pointing together with immunophenotyping to B-cell lymphoma. The dog was treated using a multi-agent chemotherapy protocol. The overall survival time was 487 days. This was an unusual case of primary gastrointestinal B-lymphoblastic lymphoma in a dog with survival equivalent to that of the multicentric form.https://vetmed.agriculturejournals.cz/artkey/vet-201801-0007_gastrointestinal-b-lymphoblastic-lymphoma-in-a-dog-a-case-report.phpcaninealimentarylymphoid neoplasiaimmunophenotypingparrchemotherapy |
| spellingShingle | P. Borska R. Husnik P. Fictum A. Kehl L. Leva M. Faldyna Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report Veterinární Medicína canine alimentary lymphoid neoplasia immunophenotyping parr chemotherapy |
| title | Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report |
| title_full | Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report |
| title_fullStr | Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report |
| title_full_unstemmed | Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report |
| title_short | Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report |
| title_sort | gastrointestinal b lymphoblastic lymphoma in a dog a case report |
| topic | canine alimentary lymphoid neoplasia immunophenotyping parr chemotherapy |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201801-0007_gastrointestinal-b-lymphoblastic-lymphoma-in-a-dog-a-case-report.php |
| work_keys_str_mv | AT pborska gastrointestinalblymphoblasticlymphomainadogacasereport AT rhusnik gastrointestinalblymphoblasticlymphomainadogacasereport AT pfictum gastrointestinalblymphoblasticlymphomainadogacasereport AT akehl gastrointestinalblymphoblasticlymphomainadogacasereport AT lleva gastrointestinalblymphoblasticlymphomainadogacasereport AT mfaldyna gastrointestinalblymphoblasticlymphomainadogacasereport |