Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectives
Gastric cancer (GC) is a malignant tumor that originates from the epithelium of the gastric mucosa. The latest global cancer statistics show that GC ranks fifth in incidence and fourth in mortality among all cancers, posing a serious threat to public health. While early-stage GC is primarily treated...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-04-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224001914 |
| _version_ | 1797248451549855744 |
|---|---|
| author | Jiahua Liu Qihang Yuan Hui Guo Hewen Guan Zhijun Hong Dong Shang |
| author_facet | Jiahua Liu Qihang Yuan Hui Guo Hewen Guan Zhijun Hong Dong Shang |
| author_sort | Jiahua Liu |
| collection | DOAJ |
| description | Gastric cancer (GC) is a malignant tumor that originates from the epithelium of the gastric mucosa. The latest global cancer statistics show that GC ranks fifth in incidence and fourth in mortality among all cancers, posing a serious threat to public health. While early-stage GC is primarily treated through surgery, chemotherapy is the frontline option for advanced cases. Currently, commonly used chemotherapy regimens include FOLFOX (oxaliplatin + leucovorin + 5-fluorouracil) and XELOX (oxaliplatin + capecitabine). However, with the widespread use of chemotherapy, an increasing number of cases of drug resistance have emerged. This article primarily explores the potential mechanisms of chemotherapy resistance in GC patients from five perspectives: cell death, tumor microenvironment, non-coding RNA, epigenetics, and epithelial-mesenchymal transition. Additionally, it proposes feasibility strategies to overcome drug resistance from four angles: cancer stem cells, tumor microenvironment, natural products, and combined therapy. The hope is that this article will provide guidance for researchers in the field and bring hope to more GC patients. |
| first_indexed | 2024-03-07T22:55:50Z |
| format | Article |
| id | doaj.art-fbeff93da2a748b5a5abb403f1436e29 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-24T20:14:48Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-fbeff93da2a748b5a5abb403f1436e292024-03-23T06:22:43ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-04-01173116310Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectivesJiahua Liu0Qihang Yuan1Hui Guo2Hewen Guan3Zhijun Hong4Dong Shang5First Affiliated Hospital of Dalian Medical University, Dalian, ChinaFirst Affiliated Hospital of Dalian Medical University, Dalian, ChinaFirst Affiliated Hospital of Dalian Medical University, Dalian, ChinaCorresponding authors.; First Affiliated Hospital of Dalian Medical University, Dalian, ChinaCorresponding authors.; First Affiliated Hospital of Dalian Medical University, Dalian, ChinaCorresponding authors.; First Affiliated Hospital of Dalian Medical University, Dalian, ChinaGastric cancer (GC) is a malignant tumor that originates from the epithelium of the gastric mucosa. The latest global cancer statistics show that GC ranks fifth in incidence and fourth in mortality among all cancers, posing a serious threat to public health. While early-stage GC is primarily treated through surgery, chemotherapy is the frontline option for advanced cases. Currently, commonly used chemotherapy regimens include FOLFOX (oxaliplatin + leucovorin + 5-fluorouracil) and XELOX (oxaliplatin + capecitabine). However, with the widespread use of chemotherapy, an increasing number of cases of drug resistance have emerged. This article primarily explores the potential mechanisms of chemotherapy resistance in GC patients from five perspectives: cell death, tumor microenvironment, non-coding RNA, epigenetics, and epithelial-mesenchymal transition. Additionally, it proposes feasibility strategies to overcome drug resistance from four angles: cancer stem cells, tumor microenvironment, natural products, and combined therapy. The hope is that this article will provide guidance for researchers in the field and bring hope to more GC patients.http://www.sciencedirect.com/science/article/pii/S0753332224001914Gastric cancerDrug resistanceMechanismPerspectives |
| spellingShingle | Jiahua Liu Qihang Yuan Hui Guo Hewen Guan Zhijun Hong Dong Shang Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectives Biomedicine & Pharmacotherapy Gastric cancer Drug resistance Mechanism Perspectives |
| title | Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectives |
| title_full | Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectives |
| title_fullStr | Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectives |
| title_full_unstemmed | Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectives |
| title_short | Deciphering drug resistance in gastric cancer: Potential mechanisms and future perspectives |
| title_sort | deciphering drug resistance in gastric cancer potential mechanisms and future perspectives |
| topic | Gastric cancer Drug resistance Mechanism Perspectives |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224001914 |
| work_keys_str_mv | AT jiahualiu decipheringdrugresistanceingastriccancerpotentialmechanismsandfutureperspectives AT qihangyuan decipheringdrugresistanceingastriccancerpotentialmechanismsandfutureperspectives AT huiguo decipheringdrugresistanceingastriccancerpotentialmechanismsandfutureperspectives AT hewenguan decipheringdrugresistanceingastriccancerpotentialmechanismsandfutureperspectives AT zhijunhong decipheringdrugresistanceingastriccancerpotentialmechanismsandfutureperspectives AT dongshang decipheringdrugresistanceingastriccancerpotentialmechanismsandfutureperspectives |