Fully Human Herpesvirus-Specific Neutralizing IgG Antibodies Generated by EBV Immortalization of Splenocytes-Derived from Immunized Humanized Mice

Fully Human Herpesvirus-Specific Neutralizing IgG Antibodies Generated by EBV Immortalization of Splenocytes-Derived from Immunized Humanized Mice

Antiviral neutralizing antibodies (nAbs) are commonly derived from B cells developed in immunized or infected animals and humans. Fully human antibodies are preferred for clinical use as they are potentially less immunogenic. However, the function of B cells varies depending on their homing pattern...

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Bibliographic Details
Main Authors: Sebastian J. Theobald, Elena Fiestas, Andreas Schneider, Benjamin Ostermann, Simon Danisch, Constantin von Kaisenberg, Jan Rybniker, Wolfgang Hammerschmidt, Reinhard Zeidler, Renata Stripecke
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
HCMV
EBV
herpesvirus
humanized mice
antibodies
immortalization
Online Access:https://www.mdpi.com/2073-4409/13/1/20

Internet

https://www.mdpi.com/2073-4409/13/1/20

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