Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus
Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2016-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/22/7/16-0022_article |
| _version_ | 1811216547095511040 |
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| author | Timothy M. Uyeki Karl J. Erlandson George Korch Michael O’Hara Michael Wathen Jean Hu-Primmer Sally Hojvat Erik J. Stemmy Armen Donabedian |
| author_facet | Timothy M. Uyeki Karl J. Erlandson George Korch Michael O’Hara Michael Wathen Jean Hu-Primmer Sally Hojvat Erik J. Stemmy Armen Donabedian |
| author_sort | Timothy M. Uyeki |
| collection | DOAJ |
| description | Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical countermeasures; development of MERS-CoV diagnostics; improved access to nonhuman primates to support preclinical research; studies to better understand and control MERS-CoV disease, including vaccination studies in camels; and development of a standardized clinical trial protocol. Partnering with clinical trial networks in affected countries to evaluate safety and efficacy of investigational therapeutics will strengthen efforts to identify successful medical countermeasures. |
| first_indexed | 2024-04-12T06:40:57Z |
| format | Article |
| id | doaj.art-fbf4856a2ea34c609ba3ec9910b66406 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T06:40:57Z |
| publishDate | 2016-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-fbf4856a2ea34c609ba3ec9910b664062022-12-22T03:43:43ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592016-07-0122710.3201/eid2207.160022Development of Medical Countermeasures to Middle East Respiratory Syndrome CoronavirusTimothy M. UyekiKarl J. ErlandsonGeorge KorchMichael O’HaraMichael WathenJean Hu-PrimmerSally HojvatErik J. StemmyArmen DonabedianPreclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical countermeasures; development of MERS-CoV diagnostics; improved access to nonhuman primates to support preclinical research; studies to better understand and control MERS-CoV disease, including vaccination studies in camels; and development of a standardized clinical trial protocol. Partnering with clinical trial networks in affected countries to evaluate safety and efficacy of investigational therapeutics will strengthen efforts to identify successful medical countermeasures.https://wwwnc.cdc.gov/eid/article/22/7/16-0022_articleMiddle East respiratory syndrome coronavirusMERS-CoVmedical countermeasuresanimal modelsnon-human primatesNHPs |
| spellingShingle | Timothy M. Uyeki Karl J. Erlandson George Korch Michael O’Hara Michael Wathen Jean Hu-Primmer Sally Hojvat Erik J. Stemmy Armen Donabedian Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus Emerging Infectious Diseases Middle East respiratory syndrome coronavirus MERS-CoV medical countermeasures animal models non-human primates NHPs |
| title | Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus |
| title_full | Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus |
| title_fullStr | Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus |
| title_full_unstemmed | Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus |
| title_short | Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus |
| title_sort | development of medical countermeasures to middle east respiratory syndrome coronavirus |
| topic | Middle East respiratory syndrome coronavirus MERS-CoV medical countermeasures animal models non-human primates NHPs |
| url | https://wwwnc.cdc.gov/eid/article/22/7/16-0022_article |
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