基于网络药理学和分子对接探讨复羽叶栾树种仁油治疗脂肪肝的作用机制Mechanism of action of Koelreuteria bipinnata seed oil in the treatment of fatty liver based on network pharmacology and molecular docking

基于网络药理学和分子对接探讨复羽叶栾树种仁油治疗脂肪肝的作用机制Mechanism of action of Koelreuteria bipinnata seed oil in the treatment of fatty liver based on network pharmacology and molecular docking

为了探究复羽叶栾树种仁油活性成分可能作用于脂肪肝治疗的药效物质基础、潜在靶标及作用机制，基于网络药理学手段和分子对接，获得复羽叶栾树种仁油中6种核心有效成分花生一烯酸、棕榈酸、亚油酸、油酸、芥酸、花生酸，筛选出治疗脂肪肝相关靶点69个，预测可能作用于ALB、IGF1、PPARα、PPARγ、SRC 5个核心靶点蛋白，通过活性成分与靶点相互作用发挥治疗脂肪肝的作用。复羽叶栾树种仁油治疗脂肪肝具有多成分、多靶点、多通路的作用特点。 In order to investigate the possible pharmacological basis, potential targets and m...

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Bibliographic Details
Main Author:	郑蕾1，2，赵子玥1，杨文涛1，何昊1，2，张存劳1，徐玥1，2 ZHENG Lei1，2，ZHAO Ziyue1，YANG Wentao1，HE Hao1,2，ZHANG Cunlao1，XU Yue1，2
Format:	Article
Language:	English
Published:	中粮工科（西安）国际工程有限公司 2023-07-01
Series:	Zhongguo youzhi
Subjects:	复羽叶栾树种仁油；脂肪肝；网络药理学；分子对接 koelreuteria bipinnata seed oil; fatty liver; network pharmacology; molecular docking
Online Access:	http://tg.chinaoils.cn/ch/reader/create_pdf.aspx?file_no=20230717&flag=1

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