Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, inc...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1143 |
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| author | Abdallah Mohammad Ibrahim Lalita Chauhan Aditi Bhardwaj Anjali Sharma Faizana Fayaz Bhumika Kumar Mohamed Alhashmi Noora AlHajri Md Sabir Alam Faheem Hyder Pottoo |
| author_facet | Abdallah Mohammad Ibrahim Lalita Chauhan Aditi Bhardwaj Anjali Sharma Faizana Fayaz Bhumika Kumar Mohamed Alhashmi Noora AlHajri Md Sabir Alam Faheem Hyder Pottoo |
| author_sort | Abdallah Mohammad Ibrahim |
| collection | DOAJ |
| description | Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells. Several studies have shown that decrease in BDNF causes an imbalance in neuronal functioning and survival. Moreover, BDNF has several important roles, such as improving synaptic plasticity and contributing to long-lasting memory formation. BDNF has been linked to the pathology of the most common neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. This review aims to describe recent efforts to understand the connection between the level of BDNF and neurodegenerative diseases. Several studies have shown that a high level of BDNF is associated with a lower risk for developing a neurodegenerative disease. |
| first_indexed | 2024-03-10T03:17:04Z |
| format | Article |
| id | doaj.art-fbf7858f8225492aba2c62bad6989bfb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:17:04Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fbf7858f8225492aba2c62bad6989bfb2023-11-23T10:11:40ZengMDPI AGBiomedicines2227-90592022-05-01105114310.3390/biomedicines10051143Brain-Derived Neurotropic Factor in Neurodegenerative DisordersAbdallah Mohammad Ibrahim0Lalita Chauhan1Aditi Bhardwaj2Anjali Sharma3Faizana Fayaz4Bhumika Kumar5Mohamed Alhashmi6Noora AlHajri7Md Sabir Alam8Faheem Hyder Pottoo9Department of Fundamentals of Nursing, College of Nursing, Imam Abdul Rahman Bin Faisal University, Dammam 31441, Saudi ArabiaSchool of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi 173205, IndiaDepartment of Pharmaceutical Sciences, Manav Bharti University, Vill. Laddo, Sultanpur (Kumarhatti), Solan 173229, IndiaDepartment of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Sector-3, MB Road, Pushp Vihar, New Delhi 110017, IndiaDepartment of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Sector-3, MB Road, Pushp Vihar, New Delhi 110017, IndiaDepartment of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Sector-3, MB Road, Pushp Vihar, New Delhi 110017, IndiaCollege of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab EmiratesDepartment of Medicine, Sheikh Shakhbout Medical City (SSMC), Abu Dhabi P.O. Box 127788, United Arab EmiratesSGT College of Pharmacy, SGT University, Gurgaon 122505, IndiaDepartment of Pharmacology, College of Clinical Pharmacy, Imam Abdul Rahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaGlobally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells. Several studies have shown that decrease in BDNF causes an imbalance in neuronal functioning and survival. Moreover, BDNF has several important roles, such as improving synaptic plasticity and contributing to long-lasting memory formation. BDNF has been linked to the pathology of the most common neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. This review aims to describe recent efforts to understand the connection between the level of BDNF and neurodegenerative diseases. Several studies have shown that a high level of BDNF is associated with a lower risk for developing a neurodegenerative disease.https://www.mdpi.com/2227-9059/10/5/1143brain-derived neurotrophic factortropomyosin receptor kinase Bneurodegenerative disordersAlzheimer’s diseaseParkinson’s disease |
| spellingShingle | Abdallah Mohammad Ibrahim Lalita Chauhan Aditi Bhardwaj Anjali Sharma Faizana Fayaz Bhumika Kumar Mohamed Alhashmi Noora AlHajri Md Sabir Alam Faheem Hyder Pottoo Brain-Derived Neurotropic Factor in Neurodegenerative Disorders Biomedicines brain-derived neurotrophic factor tropomyosin receptor kinase B neurodegenerative disorders Alzheimer’s disease Parkinson’s disease |
| title | Brain-Derived Neurotropic Factor in Neurodegenerative Disorders |
| title_full | Brain-Derived Neurotropic Factor in Neurodegenerative Disorders |
| title_fullStr | Brain-Derived Neurotropic Factor in Neurodegenerative Disorders |
| title_full_unstemmed | Brain-Derived Neurotropic Factor in Neurodegenerative Disorders |
| title_short | Brain-Derived Neurotropic Factor in Neurodegenerative Disorders |
| title_sort | brain derived neurotropic factor in neurodegenerative disorders |
| topic | brain-derived neurotrophic factor tropomyosin receptor kinase B neurodegenerative disorders Alzheimer’s disease Parkinson’s disease |
| url | https://www.mdpi.com/2227-9059/10/5/1143 |
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