The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats
Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BC...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2023/2313503 |
| _version_ | 1797677650711412736 |
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| author | Hery D. Purnomo Refani A. Kusuma Elfrida Sianturi Ryan F. Haroen Muchamad R. Solichin Choirun Nissa Adriyan Pramono Endang Mahati Etika R. Noer |
| author_facet | Hery D. Purnomo Refani A. Kusuma Elfrida Sianturi Ryan F. Haroen Muchamad R. Solichin Choirun Nissa Adriyan Pramono Endang Mahati Etika R. Noer |
| author_sort | Hery D. Purnomo |
| collection | DOAJ |
| description | Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BCAAs) and middle-chain triglycerides (MCTs), which could repair liver tissue damage, improve the inflammatory status, and modulate SCFA in liver damage. The study aimed to determine the effect of hepatogomax on liver tissue repair, inflammation (TNF-α and IL-6), and SCFA levels in thioacetamide (TAA)-induced rats. The induction of TAA causes liver steatosis, increasing TNF-α and IL-6, and decreasing SCFA levels. Hepatogomax at a dose of 14.6 g/200 gBW significantly reduces TNF-α and IL-6 levels and increases SCFA levels (p < 0.05). The number of steatosis between groups P2 and P3 was lower as compared to a group of negative control [K2] (p < 0.05). Hepatogomax, in a dose-dependent manner, may repair liver tissue and improve inflammatory response and SCFA levels in TAA-induced rats. |
| first_indexed | 2024-03-11T22:48:21Z |
| format | Article |
| id | doaj.art-fbf845287da546879211201986db54eb |
| institution | Directory Open Access Journal |
| issn | 2090-0732 |
| language | English |
| last_indexed | 2024-03-11T22:48:21Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj.art-fbf845287da546879211201986db54eb2023-09-22T05:00:06ZengHindawi LimitedJournal of Nutrition and Metabolism2090-07322023-01-01202310.1155/2023/2313503The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced RatsHery D. Purnomo0Refani A. Kusuma1Elfrida Sianturi2Ryan F. Haroen3Muchamad R. Solichin4Choirun Nissa5Adriyan Pramono6Endang Mahati7Etika R. Noer8Division of Gastroentero-HepatologyDepartment of Nutrition ScienceDepartment of Nutrition ScienceDepartment of Anatomical PathologyDepartment of Anatomical PathologyDepartment of Nutrition ScienceDepartment of Nutrition ScienceDepartment of Pharmacology and TherapyDepartment of Nutrition ScienceLiver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BCAAs) and middle-chain triglycerides (MCTs), which could repair liver tissue damage, improve the inflammatory status, and modulate SCFA in liver damage. The study aimed to determine the effect of hepatogomax on liver tissue repair, inflammation (TNF-α and IL-6), and SCFA levels in thioacetamide (TAA)-induced rats. The induction of TAA causes liver steatosis, increasing TNF-α and IL-6, and decreasing SCFA levels. Hepatogomax at a dose of 14.6 g/200 gBW significantly reduces TNF-α and IL-6 levels and increases SCFA levels (p < 0.05). The number of steatosis between groups P2 and P3 was lower as compared to a group of negative control [K2] (p < 0.05). Hepatogomax, in a dose-dependent manner, may repair liver tissue and improve inflammatory response and SCFA levels in TAA-induced rats.http://dx.doi.org/10.1155/2023/2313503 |
| spellingShingle | Hery D. Purnomo Refani A. Kusuma Elfrida Sianturi Ryan F. Haroen Muchamad R. Solichin Choirun Nissa Adriyan Pramono Endang Mahati Etika R. Noer The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats Journal of Nutrition and Metabolism |
| title | The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats |
| title_full | The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats |
| title_fullStr | The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats |
| title_full_unstemmed | The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats |
| title_short | The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats |
| title_sort | effects of hepatogomax enteral formula on systemic inflammation caecum short chain fatty acid levels and liver histopathology in thioacetamide induced rats |
| url | http://dx.doi.org/10.1155/2023/2313503 |
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