Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue
Abstract Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofaci...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | npj Regenerative Medicine |
| Online Access: | https://doi.org/10.1038/s41536-023-00286-3 |
| _version_ | 1797865371787591680 |
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| author | Bo Wen Yuguo Dai Xue Han Fangjun Huo Li Xie Mei Yu Yuru Wang Ning An Zhonghan Li Weihua Guo |
| author_facet | Bo Wen Yuguo Dai Xue Han Fangjun Huo Li Xie Mei Yu Yuru Wang Ning An Zhonghan Li Weihua Guo |
| author_sort | Bo Wen |
| collection | DOAJ |
| description | Abstract Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca 2+ ·COO − coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration. |
| first_indexed | 2024-04-09T23:08:03Z |
| format | Article |
| id | doaj.art-fbfbdac816e24866869526e8b6710815 |
| institution | Directory Open Access Journal |
| issn | 2057-3995 |
| language | English |
| last_indexed | 2024-04-09T23:08:03Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Regenerative Medicine |
| spelling | doaj.art-fbfbdac816e24866869526e8b67108152023-03-22T10:38:35ZengNature Portfolionpj Regenerative Medicine2057-39952023-02-018112110.1038/s41536-023-00286-3Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissueBo Wen0Yuguo Dai1Xue Han2Fangjun Huo3Li Xie4Mei Yu5Yuru Wang6Ning An7Zhonghan Li8Weihua Guo9State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAbstract Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca 2+ ·COO − coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.https://doi.org/10.1038/s41536-023-00286-3 |
| spellingShingle | Bo Wen Yuguo Dai Xue Han Fangjun Huo Li Xie Mei Yu Yuru Wang Ning An Zhonghan Li Weihua Guo Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue npj Regenerative Medicine |
| title | Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue |
| title_full | Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue |
| title_fullStr | Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue |
| title_full_unstemmed | Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue |
| title_short | Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue |
| title_sort | biomineralization inspired mineralized hydrogel promotes the repair and regeneration of dentin bone hard tissue |
| url | https://doi.org/10.1038/s41536-023-00286-3 |
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