Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation

Liraglutide ameliorates oxidized LDL-induced endothelial dysfunction by GLP-1R-dependent downregulation of LOX-1-mediated oxidative stress and inflammation

ABSTRACTObjective To investigate the effects of glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on endothelial dysfunction in LDL receptor-deficient (LDLR-KO) mice and ox-LDL-challenged human umbilical vein endothelial cells (HUVECs) and its possible mechanism.Methods LDLR-KO mice were...

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Bibliographic Details
Main Authors: Wu Ying, Song Meiyan, Chen Wen, Xu Kaizu, Wu Meifang, Lin Liming
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Redox Report
Subjects:
Liraglutide
oxidized low-density lipoprotein
lectin-like ox-LDL receptor-1
endothelial dysfunction
oxidative stress
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2023.2218684

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