TRAIL signals, extracellular matrix and vessel remodelling
The extracellular matrix (ECM) is an essential part of the vasculature, not only providing structural support to the blood vessel wall, but also in its ability to interact with cells to regulate cell phenotype and function including proliferation, migration, differentiation and death – processes imp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2020-07-01
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| Series: | Vascular Biology |
| Subjects: | |
| Online Access: | https://vb.bioscientifica.com/view/journals/vb/2/1/VB-20-0005.xml |
| _version_ | 1828813041516412928 |
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| author | Manisha S Patil Siân P Cartland Mary M Kavurma |
| author_facet | Manisha S Patil Siân P Cartland Mary M Kavurma |
| author_sort | Manisha S Patil |
| collection | DOAJ |
| description | The extracellular matrix (ECM) is an essential part of the vasculature, not only providing structural support to the blood vessel wall, but also in its ability to interact with cells to regulate cell phenotype and function including proliferation, migration, differentiation and death – processes important in vascular remodelling. Increasing evidence implicates TNF-related apoptosis-inducing ligand (TRAIL) signalling in the modulation of vascular cell function and remodelling under normal and pathological conditions such as in atherosclerosis. TRAIL can also stimulate synthesis of multiple ECM components within blood vessels. This review explores the relationship between TRAIL signals, the ECM, and its implications in vessel remodelling in cardiovascular disease. |
| first_indexed | 2024-12-12T09:53:30Z |
| format | Article |
| id | doaj.art-fbfc866549314d97a8599d4f31d33e22 |
| institution | Directory Open Access Journal |
| issn | 2516-5658 2516-5658 |
| language | English |
| last_indexed | 2024-12-12T09:53:30Z |
| publishDate | 2020-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Vascular Biology |
| spelling | doaj.art-fbfc866549314d97a8599d4f31d33e222022-12-22T00:28:12ZengBioscientificaVascular Biology2516-56582516-56582020-07-0121R73R84https://doi.org/10.1530/VB-20-0005TRAIL signals, extracellular matrix and vessel remodellingManisha S Patil0Siân P Cartland1Mary M Kavurma2Heart Research Institute, Sydney, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, AustraliaHeart Research Institute, Sydney, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, AustraliaHeart Research Institute, Sydney, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, AustraliaThe extracellular matrix (ECM) is an essential part of the vasculature, not only providing structural support to the blood vessel wall, but also in its ability to interact with cells to regulate cell phenotype and function including proliferation, migration, differentiation and death – processes important in vascular remodelling. Increasing evidence implicates TNF-related apoptosis-inducing ligand (TRAIL) signalling in the modulation of vascular cell function and remodelling under normal and pathological conditions such as in atherosclerosis. TRAIL can also stimulate synthesis of multiple ECM components within blood vessels. This review explores the relationship between TRAIL signals, the ECM, and its implications in vessel remodelling in cardiovascular disease.https://vb.bioscientifica.com/view/journals/vb/2/1/VB-20-0005.xmlvascular remodellingextracellular matrixtnf-related apoptosisinducing ligand |
| spellingShingle | Manisha S Patil Siân P Cartland Mary M Kavurma TRAIL signals, extracellular matrix and vessel remodelling Vascular Biology vascular remodelling extracellular matrix tnf-related apoptosisinducing ligand |
| title | TRAIL signals, extracellular matrix and vessel remodelling |
| title_full | TRAIL signals, extracellular matrix and vessel remodelling |
| title_fullStr | TRAIL signals, extracellular matrix and vessel remodelling |
| title_full_unstemmed | TRAIL signals, extracellular matrix and vessel remodelling |
| title_short | TRAIL signals, extracellular matrix and vessel remodelling |
| title_sort | trail signals extracellular matrix and vessel remodelling |
| topic | vascular remodelling extracellular matrix tnf-related apoptosisinducing ligand |
| url | https://vb.bioscientifica.com/view/journals/vb/2/1/VB-20-0005.xml |
| work_keys_str_mv | AT manishaspatil trailsignalsextracellularmatrixandvesselremodelling AT sianpcartland trailsignalsextracellularmatrixandvesselremodelling AT marymkavurma trailsignalsextracellularmatrixandvesselremodelling |