The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

Apoptosis signal-regulating kinase 1 (ASK1) is a crucial stress sensor, directing cells toward apoptosis, differentiation, and senescence via the p38 and JNK signaling pathways. ASK1 dysregulation has been associated with cancer and inflammatory, cardiovascular, and neurodegenerative diseases, among...

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Bibliographic Details
Main Authors: Karolina Honzejkova, Dalibor Kosek, Veronika Obsilova, Tomas Obsil
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
ASK1
protein kinase
thioredoxin
MAP3K
MAPK signaling
Online Access:https://elifesciences.org/articles/95199

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