Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies

Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies

Abstract Novel 1,1-diaryl vinyl-sulfones analogues of combretastatin CA-4 were synthesized via Suzuki–Miyaura coupling method and screened for in-vitro antiproliferative activity against four human cancer cell lines: MDA-MB 231(breast cancer), HeLa (cervical cancer), A549 (lung cancer), and IMR-32 (...

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Bibliographic Details
Main Authors: Godshelp O. Egharevba, Ahmed Kamal, Omotayo O. Dosumu, Sunitha Routhu, Olatomide A. Fadare, Stephen O. Oguntoye, Stanislaus N. Njinga, Abimbola P. Oluyori
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05958-6

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https://doi.org/10.1038/s41598-022-05958-6

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