Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics
Background/Aim. Matrix metalloproteinase-9 (MMP-9) index is the ratio of active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in acute coronary syndrome (ACS). Methods. The study included 3 groups of patients (n = 87): the group 1 - non-diabetic subjects without ACS (...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2015-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400055P.pdf |
| _version_ | 1819169840886185984 |
|---|---|
| author | Popović Srđan Canović Fadil Ilić Miroljub Rafajlovski Sašo Dimitrijević-Srećković Vesna Matanović Dragana Vujović Svetlana Đorđević Predrag Gostiljac Draško |
| author_facet | Popović Srđan Canović Fadil Ilić Miroljub Rafajlovski Sašo Dimitrijević-Srećković Vesna Matanović Dragana Vujović Svetlana Đorđević Predrag Gostiljac Draško |
| author_sort | Popović Srđan |
| collection | DOAJ |
| description | Background/Aim. Matrix metalloproteinase-9 (MMP-9) index is the ratio of
active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in
acute coronary syndrome (ACS). Methods. The study included 3 groups of
patients (n = 87): the group 1 - non-diabetic subjects without ACS
(control); the group 2 - diabetic patients with ACS [subgroups with unstable
angina pectoris (UAP), myocardial infarction (MI) or reinfarction]; and the
group 3 non-diabetics patients with ACS. Total and active MMP-9 were
measured and used to create MMP-9 index. Results. MMP-9 index, as a marker
showed good sensitivity and specificity, of ACS in diabetics, with a cut-off
value over 58.2. MMP-9 was higher in the study groups than in the control
one. MMP-9 correlated with ACS occurrence and type of cardiovascular event.
A statistically significant difference was found among the groups according
to active MMP-9 (p < 0.001). The same was found with active MMP-9 between
the control and the group with MI (p < 0.001). The control was highly
statistically significantly different from the group of patients with UAP (p
< 0.01). Statically significant differences in MMP-9 index was found between
the control and the diabetics with ACS (p < 0.001). Statistically
significant difference of MMP-9 index was also found in the controls
compared to the value in non-diabetic patients with ACS (p < 0.01).
Conclusion. MMP-9 index may be a possible marker of atheromatous plaque
rupture in diabetics. |
| first_indexed | 2024-12-22T19:25:54Z |
| format | Article |
| id | doaj.art-fbfee849589942ec8975bd5d51e1f782 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-22T19:25:54Z |
| publishDate | 2015-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-fbfee849589942ec8975bd5d51e1f7822022-12-21T18:15:15ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502015-01-0172542142610.2298/VSP140204055P0042-84501400055PMatrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabeticsPopović Srđan0Canović Fadil1Ilić Miroljub2Rafajlovski Sašo3Dimitrijević-Srećković Vesna4Matanović Dragana5Vujović Svetlana6Đorđević Predrag7Gostiljac Draško8Clinical Center of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, SerbiaClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, SerbiaMilitary Medical Academy, Belgrade, SerbiaClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaClinical Center of Serbia, Clinic for Physical Medicine and Rehabilitation, Belgrade, SerbiaClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia + Military Medical Academy, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, SerbiaBackground/Aim. Matrix metalloproteinase-9 (MMP-9) index is the ratio of active MMP-9 and total MMP-9 levels. It reflects the importance of MMP-9 in acute coronary syndrome (ACS). Methods. The study included 3 groups of patients (n = 87): the group 1 - non-diabetic subjects without ACS (control); the group 2 - diabetic patients with ACS [subgroups with unstable angina pectoris (UAP), myocardial infarction (MI) or reinfarction]; and the group 3 non-diabetics patients with ACS. Total and active MMP-9 were measured and used to create MMP-9 index. Results. MMP-9 index, as a marker showed good sensitivity and specificity, of ACS in diabetics, with a cut-off value over 58.2. MMP-9 was higher in the study groups than in the control one. MMP-9 correlated with ACS occurrence and type of cardiovascular event. A statistically significant difference was found among the groups according to active MMP-9 (p < 0.001). The same was found with active MMP-9 between the control and the group with MI (p < 0.001). The control was highly statistically significantly different from the group of patients with UAP (p < 0.01). Statically significant differences in MMP-9 index was found between the control and the diabetics with ACS (p < 0.001). Statistically significant difference of MMP-9 index was also found in the controls compared to the value in non-diabetic patients with ACS (p < 0.01). Conclusion. MMP-9 index may be a possible marker of atheromatous plaque rupture in diabetics.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400055P.pdfdiabetes mellitusacute coronary syndromematrix metalloproteinase 9prognosis |
| spellingShingle | Popović Srđan Canović Fadil Ilić Miroljub Rafajlovski Sašo Dimitrijević-Srećković Vesna Matanović Dragana Vujović Svetlana Đorđević Predrag Gostiljac Draško Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics Vojnosanitetski Pregled diabetes mellitus acute coronary syndrome matrix metalloproteinase 9 prognosis |
| title | Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics |
| title_full | Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics |
| title_fullStr | Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics |
| title_full_unstemmed | Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics |
| title_short | Matrix metalloproteinase-9 index as a possible parameter for predicting acute coronary syndrome in diabetics |
| title_sort | matrix metalloproteinase 9 index as a possible parameter for predicting acute coronary syndrome in diabetics |
| topic | diabetes mellitus acute coronary syndrome matrix metalloproteinase 9 prognosis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400055P.pdf |
| work_keys_str_mv | AT popovicsrđan matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT canovicfadil matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT ilicmiroljub matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT rafajlovskisaso matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT dimitrijevicsreckovicvesna matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT matanovicdragana matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT vujovicsvetlana matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT đorđevicpredrag matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics AT gostiljacdrasko matrixmetalloproteinase9indexasapossibleparameterforpredictingacutecoronarysyndromeindiabetics |