How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?

Mesenchymal stromal cells have been the subject of an expanding number of studies over the past decades. Today, over 75,000 publications are available that shine light on the biological properties and therapeutic effects of these versatile cells in numerous pre-clinical models and early-phase clinic...

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Main Authors: Dina Mönch, Marlies E. J. Reinders, Marc H. Dahlke, Martin J. Hoogduijn
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/11/9/1419
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author Dina Mönch
Marlies E. J. Reinders
Marc H. Dahlke
Martin J. Hoogduijn
author_facet Dina Mönch
Marlies E. J. Reinders
Marc H. Dahlke
Martin J. Hoogduijn
author_sort Dina Mönch
collection DOAJ
description Mesenchymal stromal cells have been the subject of an expanding number of studies over the past decades. Today, over 75,000 publications are available that shine light on the biological properties and therapeutic effects of these versatile cells in numerous pre-clinical models and early-phase clinical trials. The massive number of papers makes it hard for researchers to comprehend the whole field, and furthermore, they give the impression that mesenchymal stromal cells are wonder cells that are curative for any condition. It is becoming increasingly difficult to dissect how and for what conditions mesenchymal stromal cells exhibit true and reproducible therapeutic effects. This article tries to address the question how to make sense of 75,000, and still counting, publications on mesenchymal stromal cells.
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spelling doaj.art-fbff9931134b43da8d9ba0b6f1bccea42023-11-23T07:58:58ZengMDPI AGCells2073-44092022-04-01119141910.3390/cells11091419How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?Dina Mönch0Marlies E. J. Reinders1Marc H. Dahlke2Martin J. Hoogduijn3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, 70376 Stuttgart, GermanyErasmus MC Transplant Institute, Department of Internal Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsDepartment of Surgery, Robert-Bosch-Hospital, 70376 Stuttgart, GermanyErasmus MC Transplant Institute, Department of Internal Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The NetherlandsMesenchymal stromal cells have been the subject of an expanding number of studies over the past decades. Today, over 75,000 publications are available that shine light on the biological properties and therapeutic effects of these versatile cells in numerous pre-clinical models and early-phase clinical trials. The massive number of papers makes it hard for researchers to comprehend the whole field, and furthermore, they give the impression that mesenchymal stromal cells are wonder cells that are curative for any condition. It is becoming increasingly difficult to dissect how and for what conditions mesenchymal stromal cells exhibit true and reproducible therapeutic effects. This article tries to address the question how to make sense of 75,000, and still counting, publications on mesenchymal stromal cells.https://www.mdpi.com/2073-4409/11/9/1419mesenchymal stromal cellcell therapyanimal modelsclinical trials
spellingShingle Dina Mönch
Marlies E. J. Reinders
Marc H. Dahlke
Martin J. Hoogduijn
How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?
Cells
mesenchymal stromal cell
cell therapy
animal models
clinical trials
title How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?
title_full How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?
title_fullStr How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?
title_full_unstemmed How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?
title_short How to Make Sense out of 75,000 Mesenchymal Stromal Cell Publications?
title_sort how to make sense out of 75 000 mesenchymal stromal cell publications
topic mesenchymal stromal cell
cell therapy
animal models
clinical trials
url https://www.mdpi.com/2073-4409/11/9/1419
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AT martinjhoogduijn howtomakesenseoutof75000mesenchymalstromalcellpublications