Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysis
ObjectiveStimulator of interferon genes (STING) is a key regulator in initiating innate immune response from sensing cytosolic DNA. Recent studies have revealed that the cGAS-STING signaling pathway has a crucial role in tumor development and progression across cancer types. Herein, we conducted a m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1244962/full |
| _version_ | 1797732698283835392 |
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| author | Younghoon Kim Younghoon Kim Nam-Yun Cho Lingyan Jin Hye Yeong Jin Hye Yeong Jin Gyeong Hoon Kang Gyeong Hoon Kang |
| author_facet | Younghoon Kim Younghoon Kim Nam-Yun Cho Lingyan Jin Hye Yeong Jin Hye Yeong Jin Gyeong Hoon Kang Gyeong Hoon Kang |
| author_sort | Younghoon Kim |
| collection | DOAJ |
| description | ObjectiveStimulator of interferon genes (STING) is a key regulator in initiating innate immune response from sensing cytosolic DNA. Recent studies have revealed that the cGAS-STING signaling pathway has a crucial role in tumor development and progression across cancer types. Herein, we conducted a meta-analysis to explore the relationship between the immunoexpression of STING and the survival outcome of patients in various solid tumors. Studies relevant to the subject were searched from PubMed, Embase, and Web of Science.ResultsEleven studies including 2,345 patients were eligible for the analysis. STING expression in tumor cells was related to improved disease-free survival/recurrence-free survival (DFS/RFS) (HR = 0.656, 95% CI = 0.455–0.946, p = 0.024) but not with overall survival (OS) (HR = 0.779, 95% CI = 0.534–1.136, p = 0.194). STING expression in stromal cells, however, did not show significant correlation with DFS/RFS and OS (HR = 0.979, 95% CI = 0.565–1.697, p-value = 0.940 and HR = 1.295, 95% CI = 0.845–1.985, p = 0.235, respectively). In a subgroup analysis, STING expression in tumor cells was associated with better DFS (HR = 0.622, 95% CI = 0.428–0.903, p = 0.012). In tumor cells, favorable DFS/RFS were also related to studies from univariate analysis and the gastrointestinal system (HR = 0.667, 95% CI = 0.482–0.923, p = 0.015 and HR = 0.566, 95% CI = 0.330–0.971, p = 0.039).ConclusionsSTING expression in tumor cells is associated with favorable outcome in solid tumors.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, registration number: CRD42023427027 |
| first_indexed | 2024-03-12T12:18:16Z |
| format | Article |
| id | doaj.art-fc00e07026dc44baa19b179148233521 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T12:18:16Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj.art-fc00e07026dc44baa19b1791482335212023-08-30T08:50:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-08-011310.3389/fonc.2023.12449621244962Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysisYounghoon Kim0Younghoon Kim1Nam-Yun Cho2Lingyan Jin3Hye Yeong Jin4Hye Yeong Jin5Gyeong Hoon Kang6Gyeong Hoon Kang7Department of Hospital Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaLaboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaLaboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaLaboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaLaboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Pathology, Seoul National University College of Medicine, Seoul, Republic of KoreaLaboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Pathology, Seoul National University College of Medicine, Seoul, Republic of KoreaObjectiveStimulator of interferon genes (STING) is a key regulator in initiating innate immune response from sensing cytosolic DNA. Recent studies have revealed that the cGAS-STING signaling pathway has a crucial role in tumor development and progression across cancer types. Herein, we conducted a meta-analysis to explore the relationship between the immunoexpression of STING and the survival outcome of patients in various solid tumors. Studies relevant to the subject were searched from PubMed, Embase, and Web of Science.ResultsEleven studies including 2,345 patients were eligible for the analysis. STING expression in tumor cells was related to improved disease-free survival/recurrence-free survival (DFS/RFS) (HR = 0.656, 95% CI = 0.455–0.946, p = 0.024) but not with overall survival (OS) (HR = 0.779, 95% CI = 0.534–1.136, p = 0.194). STING expression in stromal cells, however, did not show significant correlation with DFS/RFS and OS (HR = 0.979, 95% CI = 0.565–1.697, p-value = 0.940 and HR = 1.295, 95% CI = 0.845–1.985, p = 0.235, respectively). In a subgroup analysis, STING expression in tumor cells was associated with better DFS (HR = 0.622, 95% CI = 0.428–0.903, p = 0.012). In tumor cells, favorable DFS/RFS were also related to studies from univariate analysis and the gastrointestinal system (HR = 0.667, 95% CI = 0.482–0.923, p = 0.015 and HR = 0.566, 95% CI = 0.330–0.971, p = 0.039).ConclusionsSTING expression in tumor cells is associated with favorable outcome in solid tumors.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, registration number: CRD42023427027https://www.frontiersin.org/articles/10.3389/fonc.2023.1244962/fullmeta-analysisprognosisSTINGcarcinomaimmunohistochemistry |
| spellingShingle | Younghoon Kim Younghoon Kim Nam-Yun Cho Lingyan Jin Hye Yeong Jin Hye Yeong Jin Gyeong Hoon Kang Gyeong Hoon Kang Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysis Frontiers in Oncology meta-analysis prognosis STING carcinoma immunohistochemistry |
| title | Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysis |
| title_full | Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysis |
| title_fullStr | Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysis |
| title_short | Prognostic significance of STING expression in solid tumor: a systematic review and meta-analysis |
| title_sort | prognostic significance of sting expression in solid tumor a systematic review and meta analysis |
| topic | meta-analysis prognosis STING carcinoma immunohistochemistry |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1244962/full |
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