Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study
BackgroundFetal ductal constriction (DC) is associated with excessive polyphenol-rich food (PRF) consumption during pregnancy. However, the effect of this hemodynamic change on fetal cardiac function still needs to be elucidated. Therefore, this study aimed to evaluate the cardiac function of fetuse...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.868675/full |
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| author | Jing Ma Jing Ma Jing Ma Haiyan Cao Haiyan Cao Haiyan Cao Liu Hong Liu Hong Liu Hong Juanjuan Liu Juanjuan Liu Juanjuan Liu Xiaoyan Song Xiaoyan Song Xiaoyan Song Jiawei Shi Jiawei Shi Jiawei Shi Yi Zhang Yi Zhang Yi Zhang Li Cui Li Cui Li Cui Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie |
| author_facet | Jing Ma Jing Ma Jing Ma Haiyan Cao Haiyan Cao Haiyan Cao Liu Hong Liu Hong Liu Hong Juanjuan Liu Juanjuan Liu Juanjuan Liu Xiaoyan Song Xiaoyan Song Xiaoyan Song Jiawei Shi Jiawei Shi Jiawei Shi Yi Zhang Yi Zhang Yi Zhang Li Cui Li Cui Li Cui Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie |
| author_sort | Jing Ma |
| collection | DOAJ |
| description | BackgroundFetal ductal constriction (DC) is associated with excessive polyphenol-rich food (PRF) consumption during pregnancy. However, the effect of this hemodynamic change on fetal cardiac function still needs to be elucidated. Therefore, this study aimed to evaluate the cardiac function of fetuses with PRF-related DC and to describe serial observations of cardiac function changes.MethodsWe compared the traditional echocardiographic indices, including morphological, hemodynamic, and functional parameters, between study fetuses and controls. For global and segmental deformation analysis of the left and right ventricles, fetalHQ with the speckle-tracking technique was used to calculate sphericity index (SI), global longitudinal strain (GLS), fractional shortening (FS), fractional area change (FAC), etc. In addition, follow-up data were compared with the generalized linear model.ResultsA total of 60 DC fetuses and 60 gestational-matched controls were enrolled in our study, with 20 DC fetuses undertaking a follow-up echocardiogram after 2–3 weeks. Compared with controls, there was a distinct decrease in right ventricular GLS (RVGLS) (−13.39 ± 3.77 vs. −21.59 ± 2.51, p < 0.001), RVFAC (22.20 ± 9.56 vs. 36.01 ± 4.84, p < 0.001), left ventricular GLS (LVGLS) (−19.52 ± 3.24 vs. −23.81 ± 2.01 p < 0.001), and LVFAC (39.64 ± 7.32 vs. 44.89 ± 4.91, p = 0.004). For 24-segment FS analysis, DC fetuses showed lower FS in left ventricular (LV) segments 18–24, with no difference in LV segments 1–17. Right ventricular (RV) FS in segments 4–23 was also reduced in the DC group. The 24-segment SI analysis indicated significantly lower SI in DC than those in controls for LV segments 1–14 and RV segments 19–24. We found that the pulsatility index (PI) of ductus arteriosus (DA) was an independent variable for RVGLS (β = −0.29, p = 0.04). In 20 DC fetuses with follow-up echocardiograms, no obvious difference in myocardial deformation was found between the initial examination and follow-up data.ConclusionLeft and right ventricular performances were both impaired in DC fetuses, along with a series of morphological and hemodynamic changes. Although the state of DA constriction improved on second examinations, cardiac function was not completely restored. |
| first_indexed | 2024-12-11T16:10:45Z |
| format | Article |
| id | doaj.art-fc03730f33934577ad14496a40cacdc5 |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-11T16:10:45Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-fc03730f33934577ad14496a40cacdc52022-12-22T00:59:05ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.868675868675Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ StudyJing Ma0Jing Ma1Jing Ma2Haiyan Cao3Haiyan Cao4Haiyan Cao5Liu Hong6Liu Hong7Liu Hong8Juanjuan Liu9Juanjuan Liu10Juanjuan Liu11Xiaoyan Song12Xiaoyan Song13Xiaoyan Song14Jiawei Shi15Jiawei Shi16Jiawei Shi17Yi Zhang18Yi Zhang19Yi Zhang20Li Cui21Li Cui22Li Cui23Li Zhang24Li Zhang25Li Zhang26Mingxing Xie27Mingxing Xie28Mingxing Xie29Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Center for Medical Imaging in Hubei Province, Wuhan, ChinaHubei Province Key Laboratory of Molecular Imaging, Wuhan, ChinaBackgroundFetal ductal constriction (DC) is associated with excessive polyphenol-rich food (PRF) consumption during pregnancy. However, the effect of this hemodynamic change on fetal cardiac function still needs to be elucidated. Therefore, this study aimed to evaluate the cardiac function of fetuses with PRF-related DC and to describe serial observations of cardiac function changes.MethodsWe compared the traditional echocardiographic indices, including morphological, hemodynamic, and functional parameters, between study fetuses and controls. For global and segmental deformation analysis of the left and right ventricles, fetalHQ with the speckle-tracking technique was used to calculate sphericity index (SI), global longitudinal strain (GLS), fractional shortening (FS), fractional area change (FAC), etc. In addition, follow-up data were compared with the generalized linear model.ResultsA total of 60 DC fetuses and 60 gestational-matched controls were enrolled in our study, with 20 DC fetuses undertaking a follow-up echocardiogram after 2–3 weeks. Compared with controls, there was a distinct decrease in right ventricular GLS (RVGLS) (−13.39 ± 3.77 vs. −21.59 ± 2.51, p < 0.001), RVFAC (22.20 ± 9.56 vs. 36.01 ± 4.84, p < 0.001), left ventricular GLS (LVGLS) (−19.52 ± 3.24 vs. −23.81 ± 2.01 p < 0.001), and LVFAC (39.64 ± 7.32 vs. 44.89 ± 4.91, p = 0.004). For 24-segment FS analysis, DC fetuses showed lower FS in left ventricular (LV) segments 18–24, with no difference in LV segments 1–17. Right ventricular (RV) FS in segments 4–23 was also reduced in the DC group. The 24-segment SI analysis indicated significantly lower SI in DC than those in controls for LV segments 1–14 and RV segments 19–24. We found that the pulsatility index (PI) of ductus arteriosus (DA) was an independent variable for RVGLS (β = −0.29, p = 0.04). In 20 DC fetuses with follow-up echocardiograms, no obvious difference in myocardial deformation was found between the initial examination and follow-up data.ConclusionLeft and right ventricular performances were both impaired in DC fetuses, along with a series of morphological and hemodynamic changes. Although the state of DA constriction improved on second examinations, cardiac function was not completely restored.https://www.frontiersin.org/articles/10.3389/fcvm.2022.868675/fullfetal arterial duct constrictioncardiac functionFetalHQ24-segment fractional shortening24-segment sphericity index |
| spellingShingle | Jing Ma Jing Ma Jing Ma Haiyan Cao Haiyan Cao Haiyan Cao Liu Hong Liu Hong Liu Hong Juanjuan Liu Juanjuan Liu Juanjuan Liu Xiaoyan Song Xiaoyan Song Xiaoyan Song Jiawei Shi Jiawei Shi Jiawei Shi Yi Zhang Yi Zhang Yi Zhang Li Cui Li Cui Li Cui Li Zhang Li Zhang Li Zhang Mingxing Xie Mingxing Xie Mingxing Xie Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study Frontiers in Cardiovascular Medicine fetal arterial duct constriction cardiac function FetalHQ 24-segment fractional shortening 24-segment sphericity index |
| title | Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study |
| title_full | Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study |
| title_fullStr | Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study |
| title_full_unstemmed | Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study |
| title_short | Cardiac Function Assessment in Fetuses With Ductus Arteriosus Constriction: A Two-Dimensional Echocardiography and FetalHQ Study |
| title_sort | cardiac function assessment in fetuses with ductus arteriosus constriction a two dimensional echocardiography and fetalhq study |
| topic | fetal arterial duct constriction cardiac function FetalHQ 24-segment fractional shortening 24-segment sphericity index |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.868675/full |
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