LEPTIN INCREASES NITRIC OXIDE LEVEL VIA INCREASE IN iNOS EXPRESSION IN EARLY PREGNANT MOUSE UTERUS
Leptin is an adipokine hormone secreted primarily from the white adipose tissue and leptin levels are usually elevated in obese individuals. Leptin is known to mediate the relaxation of the uterus in the pregnant mouse by increasing Nitric Oxide (NO) synthesis in late pregnancy. The present study...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
West Bengal Veterinary Alumni Association
2023-06-01
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| Series: | Exploratory Animal and Medical Research |
| Subjects: | |
| Online Access: | https://www.animalmedicalresearch.org/Vol.13_Issue-1_June_2023/LEPTIN%20INCREASES%20NITRIC%20OXIDE.pdf |
| Summary: | Leptin is an adipokine hormone secreted primarily from the white adipose tissue and leptin levels are usually
elevated in obese individuals. Leptin is known to mediate the relaxation of the uterus in the pregnant mouse by increasing Nitric
Oxide (NO) synthesis in late pregnancy. The present study aimed to assess the effect of a pathological concentration of leptin
(3 nM) on NO synthesis in the uterus of early pregnant mice and also to evaluate its effect on the transcription of genes
responsible for NO synthesis. mRNA expression studies using real-time PCR revealed that leptin (3 nM) increased the relative
expression of the inducible Nitric Oxide synthase (iNOS) gene which also resulted in increased NO levels. The results suggest
that higher leptin levels during early pregnancy may increase NO levels in the uterus which may result in a net decrease in
uterine contractions further leading to complications in pregnancy.
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| ISSN: | 2277-470X 2319-247X |