Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders
BackgroundIn mental health, comorbidities are the norm rather than the exception. However, current meta-analytic methods for summarizing the neural correlates of mental disorders do not consider comorbidities, reducing them to a source of noise and bias rather than benefitting from their valuable in...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.807839/full |
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| author | Lydia Fortea Lydia Fortea Lydia Fortea Anton Albajes-Eizagirre Yuan-Wei Yao Yuan-Wei Yao Yuan-Wei Yao Edu Soler Norma Verdolini Norma Verdolini Norma Verdolini Norma Verdolini Alexander O. Hauson Alexander O. Hauson Adriana Fortea Adriana Fortea Adriana Fortea Adriana Fortea Adriana Fortea Santiago Madero Santiago Madero Aleix Solanes Aleix Solanes Scott C. Wollman Maria Serra-Blasco Maria Serra-Blasco Maria Serra-Blasco Toby Wise Steve Lukito Maria Picó-Pérez Maria Picó-Pérez Maria Picó-Pérez Christina Carlisi Christina Carlisi JinTao Zhang PingLei Pan Álvar Farré-Colomés Álvar Farré-Colomés Danilo Arnone Danilo Arnone Matthew J. Kempton Matthew J. Kempton Carles Soriano-Mas Carles Soriano-Mas Carles Soriano-Mas Katya Rubia Luke Norman Luke Norman Luke Norman Paolo Fusar-Poli Paolo Fusar-Poli Paolo Fusar-Poli Paolo Fusar-Poli David Mataix-Cols David Mataix-Cols Marc Valentí Marc Valentí Marc Valentí Marc Valentí Marc Valentí Esther Via Esther Via Narcis Cardoner Narcis Cardoner Narcis Cardoner Marco Solmi Marco Solmi Marco Solmi Marco Solmi Jae I. Shin Eduard Vieta Eduard Vieta Eduard Vieta Eduard Vieta Eduard Vieta Joaquim Radua Joaquim Radua Joaquim Radua Joaquim Radua |
| author_facet | Lydia Fortea Lydia Fortea Lydia Fortea Anton Albajes-Eizagirre Yuan-Wei Yao Yuan-Wei Yao Yuan-Wei Yao Edu Soler Norma Verdolini Norma Verdolini Norma Verdolini Norma Verdolini Alexander O. Hauson Alexander O. Hauson Adriana Fortea Adriana Fortea Adriana Fortea Adriana Fortea Adriana Fortea Santiago Madero Santiago Madero Aleix Solanes Aleix Solanes Scott C. Wollman Maria Serra-Blasco Maria Serra-Blasco Maria Serra-Blasco Toby Wise Steve Lukito Maria Picó-Pérez Maria Picó-Pérez Maria Picó-Pérez Christina Carlisi Christina Carlisi JinTao Zhang PingLei Pan Álvar Farré-Colomés Álvar Farré-Colomés Danilo Arnone Danilo Arnone Matthew J. Kempton Matthew J. Kempton Carles Soriano-Mas Carles Soriano-Mas Carles Soriano-Mas Katya Rubia Luke Norman Luke Norman Luke Norman Paolo Fusar-Poli Paolo Fusar-Poli Paolo Fusar-Poli Paolo Fusar-Poli David Mataix-Cols David Mataix-Cols Marc Valentí Marc Valentí Marc Valentí Marc Valentí Marc Valentí Esther Via Esther Via Narcis Cardoner Narcis Cardoner Narcis Cardoner Marco Solmi Marco Solmi Marco Solmi Marco Solmi Jae I. Shin Eduard Vieta Eduard Vieta Eduard Vieta Eduard Vieta Eduard Vieta Joaquim Radua Joaquim Radua Joaquim Radua Joaquim Radua |
| author_sort | Lydia Fortea |
| collection | DOAJ |
| description | BackgroundIn mental health, comorbidities are the norm rather than the exception. However, current meta-analytic methods for summarizing the neural correlates of mental disorders do not consider comorbidities, reducing them to a source of noise and bias rather than benefitting from their valuable information.ObjectivesWe describe and validate a novel neuroimaging meta-analytic approach that focuses on comorbidities. In addition, we present the protocol for a meta-analysis of all major mental disorders and their comorbidities.MethodsThe novel approach consists of a modification of Seed-based d Mapping—with Permutation of Subject Images (SDM-PSI) in which the linear models have no intercept. As in previous SDM meta-analyses, the dependent variable is the brain anatomical difference between patients and controls in a voxel. However, there is no primary disorder, and the independent variables are the percentages of patients with each disorder and each pair of potentially comorbid disorders. We use simulations to validate and provide an example of this novel approach, which correctly disentangled the abnormalities associated with each disorder and comorbidity. We then describe a protocol for conducting the new meta-analysis of all major mental disorders and their comorbidities. Specifically, we will include all voxel-based morphometry (VBM) studies of mental disorders for which a meta-analysis has already been published, including at least 10 studies. We will use the novel approach to analyze all included studies in two separate single linear models, one for children/adolescents and one for adults.DiscussionThe novel approach is a valid method to focus on comorbidities. The meta-analysis will yield a comprehensive atlas of the neuroanatomy of all major mental disorders and their comorbidities, which we hope might help develop potential diagnostic and therapeutic tools. |
| first_indexed | 2024-04-11T17:25:13Z |
| format | Article |
| id | doaj.art-fc065b5526c54f579a407cf5c8dd8857 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T17:25:13Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-fc065b5526c54f579a407cf5c8dd88572022-12-22T04:12:23ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-01-011210.3389/fpsyt.2021.807839807839Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental DisordersLydia Fortea0Lydia Fortea1Lydia Fortea2Anton Albajes-Eizagirre3Yuan-Wei Yao4Yuan-Wei Yao5Yuan-Wei Yao6Edu Soler7Norma Verdolini8Norma Verdolini9Norma Verdolini10Norma Verdolini11Alexander O. Hauson12Alexander O. Hauson13Adriana Fortea14Adriana Fortea15Adriana Fortea16Adriana Fortea17Adriana Fortea18Santiago Madero19Santiago Madero20Aleix Solanes21Aleix Solanes22Scott C. Wollman23Maria Serra-Blasco24Maria Serra-Blasco25Maria Serra-Blasco26Toby Wise27Steve Lukito28Maria Picó-Pérez29Maria Picó-Pérez30Maria Picó-Pérez31Christina Carlisi32Christina Carlisi33JinTao Zhang34PingLei Pan35Álvar Farré-Colomés36Álvar Farré-Colomés37Danilo Arnone38Danilo Arnone39Matthew J. Kempton40Matthew J. Kempton41Carles Soriano-Mas42Carles Soriano-Mas43Carles Soriano-Mas44Katya Rubia45Luke Norman46Luke Norman47Luke Norman48Paolo Fusar-Poli49Paolo Fusar-Poli50Paolo Fusar-Poli51Paolo Fusar-Poli52David Mataix-Cols53David Mataix-Cols54Marc Valentí55Marc Valentí56Marc Valentí57Marc Valentí58Marc Valentí59Esther Via60Esther Via61Narcis Cardoner62Narcis Cardoner63Narcis Cardoner64Marco Solmi65Marco Solmi66Marco Solmi67Marco Solmi68Jae I. Shin69Eduard Vieta70Eduard Vieta71Eduard Vieta72Eduard Vieta73Eduard Vieta74Joaquim Radua75Joaquim Radua76Joaquim Radua77Joaquim Radua78Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainDepartment of Education and Psychology, Freie Universität Berlin, Berlin, GermanyEinstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, GermanyBerlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, GermanyInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainBipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, SpainClinical Psychology PhD Program, California School of Professional Psychology, San Diego, CA, United StatesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United StatesInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, SpainDepartment of Medicine, University of Barcelona, Barcelona, Spain0Fundació Clínic per a la Recerca Biomèdica (FCRB), Barcelona, Spain1Psychiatric and Psychology Service, Hospital Clinic, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain2Schizophrenia Unit, Hospital Clinic, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain3Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Barcelona, SpainClinical Psychology PhD Program, California School of Professional Psychology, San Diego, CA, United StatesCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain4Department of Psychology, Abat Oliba CEU (“Centro de Estudios Universitarios”) University, Barcelona, Spain5Programa E-Health ICOnnecta't, Institut Català d'Oncologia, Barcelona, Spain6Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom7Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom8Live and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal9ICVS/3B's, PT Government Associate Laboratory, Braga, Portugal0Clinical Academic Center - Braga, Braga, Portugal7Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom1Division of Psychology and Language Sciences, University College London, London, United Kingdom2State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China3Department of Neurology, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Affiliated Yancheng Hospital of Southeast University, Yancheng, ChinaInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain4Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany5Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom6Department of Psychiatry and Behavioral Science, College of Medicine and Health Sciences, United Arab Emirates University (UAEU), Al Ain, United Arab Emirates6Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom7Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United KingdomCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain8Psychiatry and Mental Health Group, Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain9Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain7Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom7Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom0Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States1The Social and Behavioral Research Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD, United States7Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom2Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology, London, United Kingdom3Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy4Outreach and Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, United Kingdom5Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden6Stockholm Health Care Services, Stockholm County Council, Stockholm, SwedenInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainBipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain1Psychiatric and Psychology Service, Hospital Clinic, Barcelona, Spain7Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain8Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain3Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Barcelona, Spain9Mental Health Department, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain2Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology, London, United Kingdom0Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada1Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada2Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada3Department of Pediatrics, Yonsei University College of Medicine, Seoul, South KoreaInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, SpainDepartment of Medicine, University of Barcelona, Barcelona, SpainBipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain1Psychiatric and Psychology Service, Hospital Clinic, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain7Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom5Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, SwedenBackgroundIn mental health, comorbidities are the norm rather than the exception. However, current meta-analytic methods for summarizing the neural correlates of mental disorders do not consider comorbidities, reducing them to a source of noise and bias rather than benefitting from their valuable information.ObjectivesWe describe and validate a novel neuroimaging meta-analytic approach that focuses on comorbidities. In addition, we present the protocol for a meta-analysis of all major mental disorders and their comorbidities.MethodsThe novel approach consists of a modification of Seed-based d Mapping—with Permutation of Subject Images (SDM-PSI) in which the linear models have no intercept. As in previous SDM meta-analyses, the dependent variable is the brain anatomical difference between patients and controls in a voxel. However, there is no primary disorder, and the independent variables are the percentages of patients with each disorder and each pair of potentially comorbid disorders. We use simulations to validate and provide an example of this novel approach, which correctly disentangled the abnormalities associated with each disorder and comorbidity. We then describe a protocol for conducting the new meta-analysis of all major mental disorders and their comorbidities. Specifically, we will include all voxel-based morphometry (VBM) studies of mental disorders for which a meta-analysis has already been published, including at least 10 studies. We will use the novel approach to analyze all included studies in two separate single linear models, one for children/adolescents and one for adults.DiscussionThe novel approach is a valid method to focus on comorbidities. The meta-analysis will yield a comprehensive atlas of the neuroanatomy of all major mental disorders and their comorbidities, which we hope might help develop potential diagnostic and therapeutic tools.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.807839/fullmeta-analysismagnetic resonance imaging (MRI)seed-based d mapping (SDM)gray matter (GM)mental disordercomorbidity |
| spellingShingle | Lydia Fortea Lydia Fortea Lydia Fortea Anton Albajes-Eizagirre Yuan-Wei Yao Yuan-Wei Yao Yuan-Wei Yao Edu Soler Norma Verdolini Norma Verdolini Norma Verdolini Norma Verdolini Alexander O. Hauson Alexander O. Hauson Adriana Fortea Adriana Fortea Adriana Fortea Adriana Fortea Adriana Fortea Santiago Madero Santiago Madero Aleix Solanes Aleix Solanes Scott C. Wollman Maria Serra-Blasco Maria Serra-Blasco Maria Serra-Blasco Toby Wise Steve Lukito Maria Picó-Pérez Maria Picó-Pérez Maria Picó-Pérez Christina Carlisi Christina Carlisi JinTao Zhang PingLei Pan Álvar Farré-Colomés Álvar Farré-Colomés Danilo Arnone Danilo Arnone Matthew J. Kempton Matthew J. Kempton Carles Soriano-Mas Carles Soriano-Mas Carles Soriano-Mas Katya Rubia Luke Norman Luke Norman Luke Norman Paolo Fusar-Poli Paolo Fusar-Poli Paolo Fusar-Poli Paolo Fusar-Poli David Mataix-Cols David Mataix-Cols Marc Valentí Marc Valentí Marc Valentí Marc Valentí Marc Valentí Esther Via Esther Via Narcis Cardoner Narcis Cardoner Narcis Cardoner Marco Solmi Marco Solmi Marco Solmi Marco Solmi Jae I. Shin Eduard Vieta Eduard Vieta Eduard Vieta Eduard Vieta Eduard Vieta Joaquim Radua Joaquim Radua Joaquim Radua Joaquim Radua Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders Frontiers in Psychiatry meta-analysis magnetic resonance imaging (MRI) seed-based d mapping (SDM) gray matter (GM) mental disorder comorbidity |
| title | Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders |
| title_full | Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders |
| title_fullStr | Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders |
| title_full_unstemmed | Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders |
| title_short | Focusing on Comorbidity—A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders |
| title_sort | focusing on comorbidity a novel meta analytic approach and protocol to disentangle the specific neuroanatomy of co occurring mental disorders |
| topic | meta-analysis magnetic resonance imaging (MRI) seed-based d mapping (SDM) gray matter (GM) mental disorder comorbidity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.807839/full |
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focusingoncomorbidityanovelmetaanalyticapproachandprotocoltodisentanglethespecificneuroanatomyofcooccurringmentaldisorders AT joaquimradua focusingoncomorbidityanovelmetaanalyticapproachandprotocoltodisentanglethespecificneuroanatomyofcooccurringmentaldisorders |