Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties
Date fruit (Phoenix dactylifera) is widely used in Moroccan pharmacopoeia to treat inflammation and other diseases. For this purpose, six date fruit varieties (Boufgous, Bouskri, Bousrdon, Bousthammi, Jihl, and Majhoul) were assessed for their phenolics profile and anti-inflammatory activity. Total...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | Journal of King Saud University: Science |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364717302069 |
| _version_ | 1818320670846615552 |
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| author | Eimad dine Tariq Bouhlali Jaouad El Hilaly Jamal Ennassir Mohamed Benlyas Chakib Alem Mohamed-Yassine Amarouch Younes Filali-Zegzouti |
| author_facet | Eimad dine Tariq Bouhlali Jaouad El Hilaly Jamal Ennassir Mohamed Benlyas Chakib Alem Mohamed-Yassine Amarouch Younes Filali-Zegzouti |
| author_sort | Eimad dine Tariq Bouhlali |
| collection | DOAJ |
| description | Date fruit (Phoenix dactylifera) is widely used in Moroccan pharmacopoeia to treat inflammation and other diseases. For this purpose, six date fruit varieties (Boufgous, Bouskri, Bousrdon, Bousthammi, Jihl, and Majhoul) were assessed for their phenolics profile and anti-inflammatory activity. Total phenolic and flavonoid contents of these extracts were measured by the high-performance liquid chromatography (HPLC). Protein denaturation was assessed employing bovine serum albumin. Edema formation was induced in rat’s right hind paw and mice’s right ear using carrageenan and croton oil, respectively. Membrane stabilizing activity was estimated by the prevention of hypotonicity induced-erythrocyte membrane damage. The results showed that Gallic, Ferulic and Caffeic acids and Rutin were the most dominant among the analyzed polyphenolic compounds. With regard to anti-inflammatory activity, Bousrdoun showed highest NO scavenging ability (IC50 = 531.34 µg/mL), highest protein denaturation inhibition (IC50 = 408.64 µg/mL) as well as highest membrane stabilizing effect (IC50 = 483.61 µg/mL). However, Jihl exhibited highest reduction of ear edema (74%), while both Jihl and Bousrdoun exhibited similar and highest paw oedema (40.35%). Our findings indicate that among the investigated date varieties, Jihl and Bousrdoun are found to be the most active anti-inflammatory compounds. The difference in activities seems to be related to the variations in the phenolic and flavonoids content between date varieties. Keywords: Phoenix dactylifera, Polyphenolic compounds, Anti-inflammatory activity, Dates fruit |
| first_indexed | 2024-12-13T10:28:42Z |
| format | Article |
| id | doaj.art-fc06a02475c34b178f954696fd9ce9dd |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-12-13T10:28:42Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-fc06a02475c34b178f954696fd9ce9dd2022-12-21T23:50:57ZengElsevierJournal of King Saud University: Science1018-36472018-10-01304519526Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varietiesEimad dine Tariq Bouhlali0Jaouad El Hilaly1Jamal Ennassir2Mohamed Benlyas3Chakib Alem4Mohamed-Yassine Amarouch5Younes Filali-Zegzouti6Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl Meknes, Morocco; Biochemistry of Natural Products Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl Meknes, Morocco; Corresponding author at: Biology, Environment & Health Team, Faculty of Science and Technology Errachidia, 52000, Morocco.Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl Meknes, Morocco; Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohammed Ben Abdellah, Fez, Morocco; Regional institute of Education and Training Careers, Department of Life and Earth Sciences, Fez, MoroccoOfficial Laboratory for Analysis and Chemical Research, Casablanca, MoroccoBiology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl Meknes, MoroccoBiochemistry of Natural Products Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl Meknes, MoroccoBiology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl Meknes, Morocco; Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohammed Ben Abdellah, Fez, MoroccoBiology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl Meknes, MoroccoDate fruit (Phoenix dactylifera) is widely used in Moroccan pharmacopoeia to treat inflammation and other diseases. For this purpose, six date fruit varieties (Boufgous, Bouskri, Bousrdon, Bousthammi, Jihl, and Majhoul) were assessed for their phenolics profile and anti-inflammatory activity. Total phenolic and flavonoid contents of these extracts were measured by the high-performance liquid chromatography (HPLC). Protein denaturation was assessed employing bovine serum albumin. Edema formation was induced in rat’s right hind paw and mice’s right ear using carrageenan and croton oil, respectively. Membrane stabilizing activity was estimated by the prevention of hypotonicity induced-erythrocyte membrane damage. The results showed that Gallic, Ferulic and Caffeic acids and Rutin were the most dominant among the analyzed polyphenolic compounds. With regard to anti-inflammatory activity, Bousrdoun showed highest NO scavenging ability (IC50 = 531.34 µg/mL), highest protein denaturation inhibition (IC50 = 408.64 µg/mL) as well as highest membrane stabilizing effect (IC50 = 483.61 µg/mL). However, Jihl exhibited highest reduction of ear edema (74%), while both Jihl and Bousrdoun exhibited similar and highest paw oedema (40.35%). Our findings indicate that among the investigated date varieties, Jihl and Bousrdoun are found to be the most active anti-inflammatory compounds. The difference in activities seems to be related to the variations in the phenolic and flavonoids content between date varieties. Keywords: Phoenix dactylifera, Polyphenolic compounds, Anti-inflammatory activity, Dates fruithttp://www.sciencedirect.com/science/article/pii/S1018364717302069 |
| spellingShingle | Eimad dine Tariq Bouhlali Jaouad El Hilaly Jamal Ennassir Mohamed Benlyas Chakib Alem Mohamed-Yassine Amarouch Younes Filali-Zegzouti Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties Journal of King Saud University: Science |
| title | Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties |
| title_full | Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties |
| title_fullStr | Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties |
| title_full_unstemmed | Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties |
| title_short | Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties |
| title_sort | anti inflammatory properties and phenolic profile of six moroccan date fruit phoenix dactylifera l varieties |
| url | http://www.sciencedirect.com/science/article/pii/S1018364717302069 |
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