PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study
Abstract Background The prevalence of eosinophilic asthma in Lebanon, one of the most severe phenotypes among severe asthma, is not known. This study aimed at determining the prevalence of the eosinophilic phenotype defined as an eosinophil count ≥ 300 cells/mm3 among severe asthma patients in Leban...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-023-00815-1 |
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| author | Wajdi Abi Saleh Zuhair Alameh Zeina Aoun Bacha Joudy Bahous Pierre Bou Khalil Zahia Chahine Hassan Chami Georges Dabar Hassan Dheiny Alfred Dib Dany farhat Carla Irani Georges Juvelekian Nadim Kanj Bassam Mansour Moussa Riachi Mirna Waked Mohamad Yassine Carole Youakim Salah Zeinedine Fares Zaitoun |
| author_facet | Wajdi Abi Saleh Zuhair Alameh Zeina Aoun Bacha Joudy Bahous Pierre Bou Khalil Zahia Chahine Hassan Chami Georges Dabar Hassan Dheiny Alfred Dib Dany farhat Carla Irani Georges Juvelekian Nadim Kanj Bassam Mansour Moussa Riachi Mirna Waked Mohamad Yassine Carole Youakim Salah Zeinedine Fares Zaitoun |
| author_sort | Wajdi Abi Saleh |
| collection | DOAJ |
| description | Abstract Background The prevalence of eosinophilic asthma in Lebanon, one of the most severe phenotypes among severe asthma, is not known. This study aimed at determining the prevalence of the eosinophilic phenotype defined as an eosinophil count ≥ 300 cells/mm3 among severe asthma patients in Lebanon. Methods The Lebanese Chapter of the PREPARE study was a national, multicenter, cross-sectional observational study. Patients aged ≥ 12 years with severe asthma were identified and prospectively enrolled during clinic visits and completed the Global Initiative for Asthma (GINA) assessment of asthma control questionnaire. Patients’ health characteristics were collected from medical records and blood samples were obtained for measurement of serum IgE levels and blood eosinophils count. Results Overall, 101 patients (with mean age of 46.3 ± 17.0 years and 73.27% females) with severe asthma were included and, among them, 37% had eosinophilic phenotype, 67.3% had atopic phenotype with IgE > 100 IU/mL and 25.7% patients had overlapping atopic and eosinophilic phenotypes. Close to 80% had late-onset asthma, beyond 12 years of age, and around 85% had at least one severe exacerbation in the 12 months prior to study enrolment. The majority of participants [64.4%] had uncontrolled asthma, 24.7% had partially controlled symptoms and 10.9% had controlled symptoms. 19.8% of participants were on chronic oral corticosteroids, 78.2% had short course treatment of corticosteroids and all were prescribed a combination of inhaled corticosteroids and long-acting beta-agonist. Conclusions The majority of patients with severe asthma were uncontrolled of which 37% present with an eosinophilic phenotype, which should be taken into consideration for better management of these patients in view of the novel phenotype-specific therapeutic options. |
| first_indexed | 2024-03-09T15:06:28Z |
| format | Article |
| id | doaj.art-fc071839a9dd4442925926bfdabeaf05 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-03-09T15:06:28Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-fc071839a9dd4442925926bfdabeaf052023-11-26T13:39:00ZengBMCAllergy, Asthma & Clinical Immunology1710-14922023-09-011911910.1186/s13223-023-00815-1PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE studyWajdi Abi Saleh0Zuhair Alameh1Zeina Aoun Bacha2Joudy Bahous3Pierre Bou Khalil4Zahia Chahine5Hassan Chami6Georges Dabar7Hassan Dheiny8Alfred Dib9Dany farhat10Carla Irani11Georges Juvelekian12Nadim Kanj13Bassam Mansour14Moussa Riachi15Mirna Waked16Mohamad Yassine17Carole Youakim18Salah Zeinedine19Fares Zaitoun20Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic FoundationPulmonology Practice, Private PracticeDepartment of Pulmonology and Critical Care, Hôtel-Dieu De France Medical Center (UMC), Saint-Joseph University (USJ)Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Saint George Hospital University Medical CenterDepartment of Internal Medicine, Division of Pulmonary and Critical Care, American University of Beirut Medical CenterDepartment of Pneumology, NINI HospitalDepartment of Internal Medicine, Division of Pulmonary and Critical Care, American University of Beirut Medical CenterDepartment of Pulmonology and Critical Care, Hôtel-Dieu De France Medical Center (UMC), Saint-Joseph University (USJ)Respiratory Diseases, Allergies and Sleep Medicine, Private PracticeDepartment of Internal Medicine, Division of Pulmonology, Sacre-Coeur HospitalHammoud HospitalDepartment of Internal Medicine & Clinical Immunology at Hôtel-Dieu de France, St Joseph UniversityDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Saint George Hospital University Medical CenterDepartment of Internal Medicine, Division of Pulmonary and Critical Care, American University of Beirut Medical CenterDepartment of Pulmonary and Critical Care Medicine, Zahraa HospitalDepartment of Pulmonology and Critical Care, Hôtel-Dieu De France Medical Center (UMC), Saint-Joseph University (USJ)Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Saint George Hospital University Medical CenterHammoud HospitalDepartment of Internal Medicine, Division of Pulmonary, Mount Lebanon Hospital Balamand University Medical CenterDepartment of Internal Medicine, Division of Pulmonary and Critical Care, American University of Beirut Medical CenterDepartment of Pediatrics and Adolescent Medicine, American University of Beirut Medical CenterAbstract Background The prevalence of eosinophilic asthma in Lebanon, one of the most severe phenotypes among severe asthma, is not known. This study aimed at determining the prevalence of the eosinophilic phenotype defined as an eosinophil count ≥ 300 cells/mm3 among severe asthma patients in Lebanon. Methods The Lebanese Chapter of the PREPARE study was a national, multicenter, cross-sectional observational study. Patients aged ≥ 12 years with severe asthma were identified and prospectively enrolled during clinic visits and completed the Global Initiative for Asthma (GINA) assessment of asthma control questionnaire. Patients’ health characteristics were collected from medical records and blood samples were obtained for measurement of serum IgE levels and blood eosinophils count. Results Overall, 101 patients (with mean age of 46.3 ± 17.0 years and 73.27% females) with severe asthma were included and, among them, 37% had eosinophilic phenotype, 67.3% had atopic phenotype with IgE > 100 IU/mL and 25.7% patients had overlapping atopic and eosinophilic phenotypes. Close to 80% had late-onset asthma, beyond 12 years of age, and around 85% had at least one severe exacerbation in the 12 months prior to study enrolment. The majority of participants [64.4%] had uncontrolled asthma, 24.7% had partially controlled symptoms and 10.9% had controlled symptoms. 19.8% of participants were on chronic oral corticosteroids, 78.2% had short course treatment of corticosteroids and all were prescribed a combination of inhaled corticosteroids and long-acting beta-agonist. Conclusions The majority of patients with severe asthma were uncontrolled of which 37% present with an eosinophilic phenotype, which should be taken into consideration for better management of these patients in view of the novel phenotype-specific therapeutic options.https://doi.org/10.1186/s13223-023-00815-1Severe asthmaEosinophilic phenotypePrevalenceLebanon |
| spellingShingle | Wajdi Abi Saleh Zuhair Alameh Zeina Aoun Bacha Joudy Bahous Pierre Bou Khalil Zahia Chahine Hassan Chami Georges Dabar Hassan Dheiny Alfred Dib Dany farhat Carla Irani Georges Juvelekian Nadim Kanj Bassam Mansour Moussa Riachi Mirna Waked Mohamad Yassine Carole Youakim Salah Zeinedine Fares Zaitoun PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study Allergy, Asthma & Clinical Immunology Severe asthma Eosinophilic phenotype Prevalence Lebanon |
| title | PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study |
| title_full | PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study |
| title_fullStr | PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study |
| title_full_unstemmed | PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study |
| title_short | PRevalence of the Eosinophilic Phenotype Among SeveRE asthma patients in Lebanon: results of the PREPARE study |
| title_sort | prevalence of the eosinophilic phenotype among severe asthma patients in lebanon results of the prepare study |
| topic | Severe asthma Eosinophilic phenotype Prevalence Lebanon |
| url | https://doi.org/10.1186/s13223-023-00815-1 |
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