Clinical pharmacology and practical aspects of isavuconazole use
The steadily increasing incidence of invasive fungal infections, influenced to some extent by the COVID-19 pandemic, caused by both yeast and molds makes it necessary to improve the antifungal therapies used. Historically, azoles have held a key position with respect to a range of clinical forms and...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2023-12-01
|
| Series: | Клиническая микробиология и антимикробная химиотерапия |
| Subjects: | |
| Online Access: | https://cmac-journal.ru/publication/2023/4/cmac-2023-t25-n4-p379/cmac-2023-t25-n4-p379.pdf |
| _version_ | 1827320084716060672 |
|---|---|
| author | Veselov A.V. |
| author_facet | Veselov A.V. |
| author_sort | Veselov A.V. |
| collection | DOAJ |
| description | The steadily increasing incidence of invasive fungal infections, influenced to some extent by the COVID-19 pandemic, caused by both yeast and molds makes it necessary to improve the antifungal therapies used. Historically, azoles have held a key position with respect to a range of clinical forms and patient populations. Isavuconazole is the newest of the currently clinically available next generation triazole antimycotics approved in 2015 for the therapy of invasive aspergillosis and invasive mucormycosis. Isavuconazole is active against a variety of yeast, mycelial and dimorphic fungi. The significant advantages of isavuconazole, primarily over voriconazole and in some cases over posaconazole, make it an attractive option for the therapy of difficult patients with invasive fungal infections. These potential advantages include the absence of QTc prolongation, more predictable pharmacokinetics, a significantly less complex drug interaction profile and good tolerability, especially compared to voriconazole, availability in oral and intravenous dosage forms. This review will discuss key aspects of the clinical pharmacology of isavuconazole with a focus on invasive aspergillosis and invasive mucormycosis, including the in vitro activity of the compound against various micromycetes, pharmacokinetic and pharmacodynamic characteristics that distinguish isavuconazole from other new triazoles. The review will also present the current positioning of the drug in clinical practice, primarily based on current versions of international clinical practice guidelines. |
| first_indexed | 2024-04-25T00:39:15Z |
| format | Article |
| id | doaj.art-fc0a5979a64e4c6e9811e020eb7a22b9 |
| institution | Directory Open Access Journal |
| issn | 1684-4386 2686-9586 |
| language | Russian |
| last_indexed | 2024-04-25T00:39:15Z |
| publishDate | 2023-12-01 |
| publisher | Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy |
| record_format | Article |
| series | Клиническая микробиология и антимикробная химиотерапия |
| spelling | doaj.art-fc0a5979a64e4c6e9811e020eb7a22b92024-03-12T13:07:21ZrusInterregional Association for Clinical Microbiology and Antimicrobial ChemotherapyКлиническая микробиология и антимикробная химиотерапия1684-43862686-95862023-12-0125437939410.36488/cmac.2023.4.379-394cmac-2023-t25-n4-p379Clinical pharmacology and practical aspects of isavuconazole useVeselov A.V.0Institute of Antimicrobial Chemotherapy, Smolensk, RussiaThe steadily increasing incidence of invasive fungal infections, influenced to some extent by the COVID-19 pandemic, caused by both yeast and molds makes it necessary to improve the antifungal therapies used. Historically, azoles have held a key position with respect to a range of clinical forms and patient populations. Isavuconazole is the newest of the currently clinically available next generation triazole antimycotics approved in 2015 for the therapy of invasive aspergillosis and invasive mucormycosis. Isavuconazole is active against a variety of yeast, mycelial and dimorphic fungi. The significant advantages of isavuconazole, primarily over voriconazole and in some cases over posaconazole, make it an attractive option for the therapy of difficult patients with invasive fungal infections. These potential advantages include the absence of QTc prolongation, more predictable pharmacokinetics, a significantly less complex drug interaction profile and good tolerability, especially compared to voriconazole, availability in oral and intravenous dosage forms. This review will discuss key aspects of the clinical pharmacology of isavuconazole with a focus on invasive aspergillosis and invasive mucormycosis, including the in vitro activity of the compound against various micromycetes, pharmacokinetic and pharmacodynamic characteristics that distinguish isavuconazole from other new triazoles. The review will also present the current positioning of the drug in clinical practice, primarily based on current versions of international clinical practice guidelines.https://cmac-journal.ru/publication/2023/4/cmac-2023-t25-n4-p379/cmac-2023-t25-n4-p379.pdfantimycoticsisavuconazoleisavoconazniumtriazolesaspergillosismucormycosis |
| spellingShingle | Veselov A.V. Clinical pharmacology and practical aspects of isavuconazole use Клиническая микробиология и антимикробная химиотерапия antimycotics isavuconazole isavoconaznium triazoles aspergillosis mucormycosis |
| title | Clinical pharmacology and practical aspects of isavuconazole use |
| title_full | Clinical pharmacology and practical aspects of isavuconazole use |
| title_fullStr | Clinical pharmacology and practical aspects of isavuconazole use |
| title_full_unstemmed | Clinical pharmacology and practical aspects of isavuconazole use |
| title_short | Clinical pharmacology and practical aspects of isavuconazole use |
| title_sort | clinical pharmacology and practical aspects of isavuconazole use |
| topic | antimycotics isavuconazole isavoconaznium triazoles aspergillosis mucormycosis |
| url | https://cmac-journal.ru/publication/2023/4/cmac-2023-t25-n4-p379/cmac-2023-t25-n4-p379.pdf |
| work_keys_str_mv | AT veselovav clinicalpharmacologyandpracticalaspectsofisavuconazoleuse |