Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived products
In the face of increasing bacterial resistance to antibiotics currently in use, the search for new antimicrobial agents has received a boost in recent years, with natural products playing an important role in this field. In fact, several methods have been proposed to investigate the antibacterial ac...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-09-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01466/full |
| _version_ | 1818296580837474304 |
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| author | Bruno Souza dos Santos Luis Cláudio Nascimento da Silva Túlio Diego da Silva João Francisco Silva Rodrigues Marcos Augusto Grigolin Grisotto Maria Tereza dos Santos Correia Thiago Henrique Napoleão Márcia Vanusa Da Silva Patricia Maria Guedes Paiva |
| author_facet | Bruno Souza dos Santos Luis Cláudio Nascimento da Silva Túlio Diego da Silva João Francisco Silva Rodrigues Marcos Augusto Grigolin Grisotto Maria Tereza dos Santos Correia Thiago Henrique Napoleão Márcia Vanusa Da Silva Patricia Maria Guedes Paiva |
| author_sort | Bruno Souza dos Santos |
| collection | DOAJ |
| description | In the face of increasing bacterial resistance to antibiotics currently in use, the search for new antimicrobial agents has received a boost in recent years, with natural products playing an important role in this field. In fact, several methods have been proposed to investigate the antibacterial activities of natural products. However, given that the ultimate aim is future therapeutic use as novel drugs, it is extremely necessary to elucidate their modes of action, stating the molecular effects in detail and identifying their targets in the bacterial cell. This review analyzes the application of omics technologies to understand the antibacterial mechanisms of bioactive natural products, to stimulate research interest in this area and promote scientific collaborations. Some studies have been specifically highlighted herein by examining their procedures and results (targeted proteins and metabolic pathways). These approaches have the potential to provide new insights into our comprehension of antimicrobial resistance/susceptibility, creating new perspectives for the struggle against bacteria, and leading to the development of novel products in the future. |
| first_indexed | 2024-12-13T04:05:48Z |
| format | Article |
| id | doaj.art-fc0abf7ae3ec48dd9a98c20972f84b22 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-13T04:05:48Z |
| publishDate | 2016-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-fc0abf7ae3ec48dd9a98c20972f84b222022-12-22T00:00:14ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-09-01710.3389/fmicb.2016.01466181871Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived productsBruno Souza dos Santos0Luis Cláudio Nascimento da Silva1Túlio Diego da Silva2João Francisco Silva Rodrigues3Marcos Augusto Grigolin Grisotto4Maria Tereza dos Santos Correia5Thiago Henrique Napoleão6Márcia Vanusa Da Silva7Patricia Maria Guedes Paiva8Universidade Federal de PernambucoUniversidade CeumaUniversidade Federal de PernambucoUniversidade CeumaUniversidade CeumaUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoUniversidade Federal de PernambucoIn the face of increasing bacterial resistance to antibiotics currently in use, the search for new antimicrobial agents has received a boost in recent years, with natural products playing an important role in this field. In fact, several methods have been proposed to investigate the antibacterial activities of natural products. However, given that the ultimate aim is future therapeutic use as novel drugs, it is extremely necessary to elucidate their modes of action, stating the molecular effects in detail and identifying their targets in the bacterial cell. This review analyzes the application of omics technologies to understand the antibacterial mechanisms of bioactive natural products, to stimulate research interest in this area and promote scientific collaborations. Some studies have been specifically highlighted herein by examining their procedures and results (targeted proteins and metabolic pathways). These approaches have the potential to provide new insights into our comprehension of antimicrobial resistance/susceptibility, creating new perspectives for the struggle against bacteria, and leading to the development of novel products in the future.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01466/fullGenomicsMetabolomicsProteomicsNatural ProductsTranscriptomicsantimicrobial target |
| spellingShingle | Bruno Souza dos Santos Luis Cláudio Nascimento da Silva Túlio Diego da Silva João Francisco Silva Rodrigues Marcos Augusto Grigolin Grisotto Maria Tereza dos Santos Correia Thiago Henrique Napoleão Márcia Vanusa Da Silva Patricia Maria Guedes Paiva Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived products Frontiers in Microbiology Genomics Metabolomics Proteomics Natural Products Transcriptomics antimicrobial target |
| title | Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived products |
| title_full | Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived products |
| title_fullStr | Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived products |
| title_full_unstemmed | Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived products |
| title_short | Application of Omics Technologies for evaluation of antibacterial mechanisms of action of plant-derived products |
| title_sort | application of omics technologies for evaluation of antibacterial mechanisms of action of plant derived products |
| topic | Genomics Metabolomics Proteomics Natural Products Transcriptomics antimicrobial target |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01466/full |
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