Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD), which is a group of pathological processes affecting cerebral microvessels, leads to functional loss in the elderly population and mostly presents as cognitive impairment and gait decline. CSVD is diagnosed based on brain imaging biomarkers, but blood biomarkers...
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MDPI AG
2024-03-01
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| Online Access: | https://www.mdpi.com/2076-3425/14/3/269 |
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| author | Qianqian Kong Xinxin Xie Ziyue Wang Yi Zhang Xirui Zhou Lingshan Wu Zhiyuan Yu Hao Huang Xiang Luo |
| author_facet | Qianqian Kong Xinxin Xie Ziyue Wang Yi Zhang Xirui Zhou Lingshan Wu Zhiyuan Yu Hao Huang Xiang Luo |
| author_sort | Qianqian Kong |
| collection | DOAJ |
| description | Cerebral small vessel disease (CSVD), which is a group of pathological processes affecting cerebral microvessels, leads to functional loss in the elderly population and mostly presents as cognitive impairment and gait decline. CSVD is diagnosed based on brain imaging biomarkers, but blood biomarkers are of great significance for the early diagnosis and progression prediction of CSVD and have become a research focus because of their noninvasiveness and easy accessibility. Notably, many blood biomarkers have been reported to be associated with CSVD in a relatively large population, particularly serum neurofilament light chain (NfL), which has been regarded as a promising biomarker to track the variation trend in WMH and to predict the further status of white matter hyperintensities (WMH) and lacunar infarcts. And neuro-glio-vascular unit structure and blood–brain barrier function have been proposed as underlying mechanisms of CSVD. The article starts from the neuroimaging markers of CSVD, including recent small subcortical infarcts (RSSI), white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMB), enlarged perivascular spaces (EPVS), cerebral atrophy, and the combined small vessel disease score, and attempts to systematically review and summarize the research progress regarding the blood biomarkers of CSVD that form the changes in the neuro-glio-vascular unit structure and blood–brain barrier function. |
| first_indexed | 2024-04-24T18:29:39Z |
| format | Article |
| id | doaj.art-fc0f950123ec47db9c942f9394098951 |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-24T18:29:39Z |
| publishDate | 2024-03-01 |
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| series | Brain Sciences |
| spelling | doaj.art-fc0f950123ec47db9c942f93940989512024-03-27T13:28:49ZengMDPI AGBrain Sciences2076-34252024-03-0114326910.3390/brainsci14030269Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel DiseaseQianqian Kong0Xinxin Xie1Ziyue Wang2Yi Zhang3Xirui Zhou4Lingshan Wu5Zhiyuan Yu6Hao Huang7Xiang Luo8Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaCerebral small vessel disease (CSVD), which is a group of pathological processes affecting cerebral microvessels, leads to functional loss in the elderly population and mostly presents as cognitive impairment and gait decline. CSVD is diagnosed based on brain imaging biomarkers, but blood biomarkers are of great significance for the early diagnosis and progression prediction of CSVD and have become a research focus because of their noninvasiveness and easy accessibility. Notably, many blood biomarkers have been reported to be associated with CSVD in a relatively large population, particularly serum neurofilament light chain (NfL), which has been regarded as a promising biomarker to track the variation trend in WMH and to predict the further status of white matter hyperintensities (WMH) and lacunar infarcts. And neuro-glio-vascular unit structure and blood–brain barrier function have been proposed as underlying mechanisms of CSVD. The article starts from the neuroimaging markers of CSVD, including recent small subcortical infarcts (RSSI), white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMB), enlarged perivascular spaces (EPVS), cerebral atrophy, and the combined small vessel disease score, and attempts to systematically review and summarize the research progress regarding the blood biomarkers of CSVD that form the changes in the neuro-glio-vascular unit structure and blood–brain barrier function.https://www.mdpi.com/2076-3425/14/3/269cerebral small vessel diseaseblood biomarkersreview |
| spellingShingle | Qianqian Kong Xinxin Xie Ziyue Wang Yi Zhang Xirui Zhou Lingshan Wu Zhiyuan Yu Hao Huang Xiang Luo Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease Brain Sciences cerebral small vessel disease blood biomarkers review |
| title | Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease |
| title_full | Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease |
| title_fullStr | Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease |
| title_full_unstemmed | Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease |
| title_short | Correlations of Plasma Biomarkers and Imaging Characteristics of Cerebral Small Vessel Disease |
| title_sort | correlations of plasma biomarkers and imaging characteristics of cerebral small vessel disease |
| topic | cerebral small vessel disease blood biomarkers review |
| url | https://www.mdpi.com/2076-3425/14/3/269 |
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