Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting
Abstract Background Coordinated scaled-up malaria control interventions have substantially contributed to the dramatic decrease of malaria-related morbidity and mortality in several endemic countries, including Senegal. However, the impacts of a given malaria control intervention on vector and paras...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12936-017-1928-3 |
| _version_ | 1811292578051522560 |
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| author | Makhtar Niang Oumy Niass Nafissatou Diagne Fatoumata Diene Sarr Michel Matar Faye Fode Diop Babacar Diouf Joseph Faye Abdoulaye Badiane Ronald Perraut Cheikh Sokhna Jean-François Trape Adama Tall Aissatou Toure-Balde |
| author_facet | Makhtar Niang Oumy Niass Nafissatou Diagne Fatoumata Diene Sarr Michel Matar Faye Fode Diop Babacar Diouf Joseph Faye Abdoulaye Badiane Ronald Perraut Cheikh Sokhna Jean-François Trape Adama Tall Aissatou Toure-Balde |
| author_sort | Makhtar Niang |
| collection | DOAJ |
| description | Abstract Background Coordinated scaled-up malaria control interventions have substantially contributed to the dramatic decrease of malaria-related morbidity and mortality in several endemic countries, including Senegal. However, the impacts of a given malaria control intervention on vector and parasite populations, acquired immunity, and disease burden remain very poorly documented largely due to the lack of continuous surveys. This study took advantage of the sera bank established as part of the Dielmo longitudinal project to investigate the dynamics of IgG antibody responses that accompanied the epidemiological changes resulting from malaria control interventions. Schizonts crude extract of a local strain of Plasmodium falciparum (Pfsch07/03) was used in ELISA to measure and compare seroprevalence and magnitude of IgG antibody responses from 2000 to 2012. Results The prevalence of Pfsch07/03 IgG antibody responses progressively decreased from 97.25% in 2000 to 57.3% in 2012. The prevalence of Pfsch07/03 antibodies categorized between three different age groups (<7, 7–15, and >15 years) revealed increased seroprevalence with age ranging from 47.19 to 62.67 and 89.45%, respectively in (<7, 7–15, and >15 years) old age groups. A marked drop in seroprevalence was observed after 2008 and was significant in the younger (<7 years) and intermediate (7–15 years) age groups, unlike older individuals aged >15 years (p = 1.00). Conclusions The study revealed a substantial contribution of all malaria control interventions to the decrease of IgG antibodies responses to Pfsch07/03 throughout prevention of human-mosquitos contacts, or reduction of parasite biomass. The present study demonstrates the wider potential of sero-epidemiological analysis in monitoring changes in malaria transmission resulting from a given malaria control intervention. |
| first_indexed | 2024-04-13T04:47:28Z |
| format | Article |
| id | doaj.art-fc0f9e52c68b4f85bdb786e9c6e1b880 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-13T04:47:28Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-fc0f9e52c68b4f85bdb786e9c6e1b8802022-12-22T03:01:48ZengBMCMalaria Journal1475-28752017-07-011611810.1186/s12936-017-1928-3Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African settingMakhtar Niang0Oumy Niass1Nafissatou Diagne2Fatoumata Diene Sarr3Michel Matar Faye4Fode Diop5Babacar Diouf6Joseph Faye7Abdoulaye Badiane8Ronald Perraut9Cheikh Sokhna10Jean-François Trape11Adama Tall12Aissatou Toure-Balde13Immunology Unit, Institut Pasteur DakarImmunology Unit, Institut Pasteur DakarInstitut de Recherche pour le développementEpidemiology of Infectious Diseases Unit, Institut Pasteur DakarImmunology Unit, Institut Pasteur DakarImmunology Unit, Institut Pasteur DakarImmunology Unit, Institut Pasteur DakarEpidemiology of Infectious Diseases Unit, Institut Pasteur DakarEpidemiology of Infectious Diseases Unit, Institut Pasteur DakarImmunology Unit, Institut Pasteur DakarInstitut de Recherche pour le développementInstitut de Recherche pour le développementEpidemiology of Infectious Diseases Unit, Institut Pasteur DakarImmunology Unit, Institut Pasteur DakarAbstract Background Coordinated scaled-up malaria control interventions have substantially contributed to the dramatic decrease of malaria-related morbidity and mortality in several endemic countries, including Senegal. However, the impacts of a given malaria control intervention on vector and parasite populations, acquired immunity, and disease burden remain very poorly documented largely due to the lack of continuous surveys. This study took advantage of the sera bank established as part of the Dielmo longitudinal project to investigate the dynamics of IgG antibody responses that accompanied the epidemiological changes resulting from malaria control interventions. Schizonts crude extract of a local strain of Plasmodium falciparum (Pfsch07/03) was used in ELISA to measure and compare seroprevalence and magnitude of IgG antibody responses from 2000 to 2012. Results The prevalence of Pfsch07/03 IgG antibody responses progressively decreased from 97.25% in 2000 to 57.3% in 2012. The prevalence of Pfsch07/03 antibodies categorized between three different age groups (<7, 7–15, and >15 years) revealed increased seroprevalence with age ranging from 47.19 to 62.67 and 89.45%, respectively in (<7, 7–15, and >15 years) old age groups. A marked drop in seroprevalence was observed after 2008 and was significant in the younger (<7 years) and intermediate (7–15 years) age groups, unlike older individuals aged >15 years (p = 1.00). Conclusions The study revealed a substantial contribution of all malaria control interventions to the decrease of IgG antibodies responses to Pfsch07/03 throughout prevention of human-mosquitos contacts, or reduction of parasite biomass. The present study demonstrates the wider potential of sero-epidemiological analysis in monitoring changes in malaria transmission resulting from a given malaria control intervention.http://link.springer.com/article/10.1186/s12936-017-1928-3MalariaTransmissionImmunityControls |
| spellingShingle | Makhtar Niang Oumy Niass Nafissatou Diagne Fatoumata Diene Sarr Michel Matar Faye Fode Diop Babacar Diouf Joseph Faye Abdoulaye Badiane Ronald Perraut Cheikh Sokhna Jean-François Trape Adama Tall Aissatou Toure-Balde Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting Malaria Journal Malaria Transmission Immunity Controls |
| title | Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting |
| title_full | Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting |
| title_fullStr | Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting |
| title_full_unstemmed | Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting |
| title_short | Temporal analysis of IgG antibody responses to Plasmodium falciparum antigens in relation to changing malaria epidemiology in a West African setting |
| title_sort | temporal analysis of igg antibody responses to plasmodium falciparum antigens in relation to changing malaria epidemiology in a west african setting |
| topic | Malaria Transmission Immunity Controls |
| url | http://link.springer.com/article/10.1186/s12936-017-1928-3 |
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