The Search for a Schistosomiasis Vaccine: Australia’s Contribution
Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus <i>Schistosoma</i>, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug prazi...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/8/872 |
| _version_ | 1797521903799238656 |
|---|---|
| author | Donald P. McManus |
| author_facet | Donald P. McManus |
| author_sort | Donald P. McManus |
| collection | DOAJ |
| description | Schistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus <i>Schistosoma</i>, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficacious and safe against the adult parasites of all <i>Schistosoma</i> species infecting humans; however, it does not prevent reinfection and the development of drug resistance is a constant concern. The need to develop an effective vaccine is of great importance if the health of many in the developing world is to be improved. Indeed, vaccination, in combination with other public health measures, can provide an invaluable tool to achieve lasting control, leading to schistosomiasis elimination. Australia has played a leading role in schistosomiasis vaccine research over many years and this review presents an overview of some of the significant contributions made by Australian scientists in this important area. |
| first_indexed | 2024-03-10T08:19:07Z |
| format | Article |
| id | doaj.art-fc0faacbe4564131a4230f617c51abdc |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T08:19:07Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-fc0faacbe4564131a4230f617c51abdc2023-11-22T10:07:15ZengMDPI AGVaccines2076-393X2021-08-019887210.3390/vaccines9080872The Search for a Schistosomiasis Vaccine: Australia’s ContributionDonald P. McManus0Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane 4006, AustraliaSchistosomiasis, a neglected tropical disease caused by parasitic flatworms of the genus <i>Schistosoma</i>, results in considerable human morbidity in sub-Saharan Africa, in particular, but also parts of the Middle East, South America, and Southeast Asia. The anti-schistosome drug praziquantel is efficacious and safe against the adult parasites of all <i>Schistosoma</i> species infecting humans; however, it does not prevent reinfection and the development of drug resistance is a constant concern. The need to develop an effective vaccine is of great importance if the health of many in the developing world is to be improved. Indeed, vaccination, in combination with other public health measures, can provide an invaluable tool to achieve lasting control, leading to schistosomiasis elimination. Australia has played a leading role in schistosomiasis vaccine research over many years and this review presents an overview of some of the significant contributions made by Australian scientists in this important area.https://www.mdpi.com/2076-393X/9/8/872<i>Schistosoma</i>schistosomiasisvaccinevaccinationAustraliaAustralian researchers |
| spellingShingle | Donald P. McManus The Search for a Schistosomiasis Vaccine: Australia’s Contribution Vaccines <i>Schistosoma</i> schistosomiasis vaccine vaccination Australia Australian researchers |
| title | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
| title_full | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
| title_fullStr | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
| title_full_unstemmed | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
| title_short | The Search for a Schistosomiasis Vaccine: Australia’s Contribution |
| title_sort | search for a schistosomiasis vaccine australia s contribution |
| topic | <i>Schistosoma</i> schistosomiasis vaccine vaccination Australia Australian researchers |
| url | https://www.mdpi.com/2076-393X/9/8/872 |
| work_keys_str_mv | AT donaldpmcmanus thesearchforaschistosomiasisvaccineaustraliascontribution AT donaldpmcmanus searchforaschistosomiasisvaccineaustraliascontribution |