Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability
The aim of this work is to improve the solubility and bioavailability of chlortetracycline and the function of the immune response. Chlortetracycline bisulfate and chlortetracycline mesylate were successfully synthesized and characterized with several techniques, including spectroscopy, chromatograp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2020-12-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2020-0041 |
| _version_ | 1818586829288374272 |
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| author | Liu Deng Chen Peixing Yang Xu Wang Jianhua |
| author_facet | Liu Deng Chen Peixing Yang Xu Wang Jianhua |
| author_sort | Liu Deng |
| collection | DOAJ |
| description | The aim of this work is to improve the solubility and bioavailability of chlortetracycline and the function of the immune response. Chlortetracycline bisulfate and chlortetracycline mesylate were successfully synthesized and characterized with several techniques, including spectroscopy, chromatography and mass spectrometry, which demonstrated that the C4-dimethylamino group of chlortetracycline can accept a proton from sulfuric acid and methanesulfonic acid to form the corresponding salts. In addition, chlortetracycline bisulfate and chlortetracycline mesylate were more soluble in water than chlortetracycline hydrochloride, but the antibacterial activity was not enhanced. The influences of chlortetracycline hydrochloride, chlortetracycline bisulfate and chlortetracycline mesylate on chlortetracycline and immunoglobulin concentrations in mouse serum were also investigated. These results suggested that the chlortetracycline bisulfate and chlortetracycline mesylate have good bioavailability and strong immune response and have potential applications in animal breeding and formulation technologies. |
| first_indexed | 2024-12-16T08:59:11Z |
| format | Article |
| id | doaj.art-fc0fe730f4aa45dca7d7447af25e493a |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-12-16T08:59:11Z |
| publishDate | 2020-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-fc0fe730f4aa45dca7d7447af25e493a2022-12-21T22:37:13ZengSciendoActa Pharmaceutica1846-95582020-12-0170448349810.2478/acph-2020-0041acph-2020-0041Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailabilityLiu Deng0Chen Peixing1Yang Xu2Wang Jianhua3Key Laboratory of Biorheological Science and Technology, Ministry of Education Bioengineering College, Chongqing University, Chongqing, 400044 People’s Republic of ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education Bioengineering College, Chongqing University, Chongqing, 400044 People’s Republic of ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education Bioengineering College, Chongqing University, Chongqing, 400044 People’s Republic of ChinaKey Laboratory of Biorheological Science and Technology, Ministry of Education Bioengineering College, Chongqing University, Chongqing, 400044 People’s Republic of ChinaThe aim of this work is to improve the solubility and bioavailability of chlortetracycline and the function of the immune response. Chlortetracycline bisulfate and chlortetracycline mesylate were successfully synthesized and characterized with several techniques, including spectroscopy, chromatography and mass spectrometry, which demonstrated that the C4-dimethylamino group of chlortetracycline can accept a proton from sulfuric acid and methanesulfonic acid to form the corresponding salts. In addition, chlortetracycline bisulfate and chlortetracycline mesylate were more soluble in water than chlortetracycline hydrochloride, but the antibacterial activity was not enhanced. The influences of chlortetracycline hydrochloride, chlortetracycline bisulfate and chlortetracycline mesylate on chlortetracycline and immunoglobulin concentrations in mouse serum were also investigated. These results suggested that the chlortetracycline bisulfate and chlortetracycline mesylate have good bioavailability and strong immune response and have potential applications in animal breeding and formulation technologies.https://doi.org/10.2478/acph-2020-0041chlortetracyclinepharmaceutical saltsolubilitybioavailabilityantibacterial activityimmunoglobulin |
| spellingShingle | Liu Deng Chen Peixing Yang Xu Wang Jianhua Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability Acta Pharmaceutica chlortetracycline pharmaceutical salt solubility bioavailability antibacterial activity immunoglobulin |
| title | Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability |
| title_full | Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability |
| title_fullStr | Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability |
| title_full_unstemmed | Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability |
| title_short | Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability |
| title_sort | synthesis and evaluation of bisulfate mesylate conjugated chlortetracycline with high solubility and bioavailability |
| topic | chlortetracycline pharmaceutical salt solubility bioavailability antibacterial activity immunoglobulin |
| url | https://doi.org/10.2478/acph-2020-0041 |
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