Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin
The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventiona...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2020-07-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600685&tlng=en |
| _version_ | 1798020570720239616 |
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| author | Lúbia G. Nascimento Suellen A. Lopes Ayron B. L. Teodolino Kátia M. Novack Ana Paula M. Barboza Bernardo R. A. Neves Maria Luiza S. Azevedo Lucas R. D. Sousa Viviane M. R. dos Santos |
| author_facet | Lúbia G. Nascimento Suellen A. Lopes Ayron B. L. Teodolino Kátia M. Novack Ana Paula M. Barboza Bernardo R. A. Neves Maria Luiza S. Azevedo Lucas R. D. Sousa Viviane M. R. dos Santos |
| author_sort | Lúbia G. Nascimento |
| collection | DOAJ |
| description | The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded as drug-modulating controllers at specific sites in the body. Indomethacin has been used in the controlled release of drugs because it is a drug that have good interaction with different polymers. The drug is a non-steroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, osteoarthritis, spondylitis, and other disorders. In this work, PEG 4000 had its chain modified by organic reactions and their derivatives were emulsified to form microparticles using polyvinyl alcohol as an emulsifier. Posteriorly were also incorporated with indomethacin. The samples were characterized to prove the influence of indomethacin on the morphology and thermal behavior of this polymer. The controlled release was performed in the time from 0 to 240 min using the Ultraviolet Spectroscopy to quantify indomethacin released from the polymer matrix for these 4 hours. Releases over the time were satisfactory as concentrations increased over time, which we can conclude that the structural modification of PEG 4000 was beneficial in the release of the indomethacin drug. |
| first_indexed | 2024-04-11T16:59:43Z |
| format | Article |
| id | doaj.art-fc11490fa4d94288a40231d1cc9bf9c6 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-11T16:59:43Z |
| publishDate | 2020-07-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-fc11490fa4d94288a40231d1cc9bf9c62022-12-22T04:13:12ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642020-07-0143668569110.21577/0100-4042.20170537Novel PEG 4000 derivatives and its use in controlled release of drug indomethacinLúbia G. NascimentoSuellen A. LopesAyron B. L. TeodolinoKátia M. NovackAna Paula M. BarbozaBernardo R. A. NevesMaria Luiza S. AzevedoLucas R. D. SousaViviane M. R. dos Santoshttps://orcid.org/0000-0002-0144-9518The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded as drug-modulating controllers at specific sites in the body. Indomethacin has been used in the controlled release of drugs because it is a drug that have good interaction with different polymers. The drug is a non-steroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, osteoarthritis, spondylitis, and other disorders. In this work, PEG 4000 had its chain modified by organic reactions and their derivatives were emulsified to form microparticles using polyvinyl alcohol as an emulsifier. Posteriorly were also incorporated with indomethacin. The samples were characterized to prove the influence of indomethacin on the morphology and thermal behavior of this polymer. The controlled release was performed in the time from 0 to 240 min using the Ultraviolet Spectroscopy to quantify indomethacin released from the polymer matrix for these 4 hours. Releases over the time were satisfactory as concentrations increased over time, which we can conclude that the structural modification of PEG 4000 was beneficial in the release of the indomethacin drug.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600685&tlng=enpolyethyleneglycolindomethacinincorporationcontrolled release |
| spellingShingle | Lúbia G. Nascimento Suellen A. Lopes Ayron B. L. Teodolino Kátia M. Novack Ana Paula M. Barboza Bernardo R. A. Neves Maria Luiza S. Azevedo Lucas R. D. Sousa Viviane M. R. dos Santos Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin Química Nova polyethyleneglycol indomethacin incorporation controlled release |
| title | Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_full | Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_fullStr | Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_full_unstemmed | Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_short | Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin |
| title_sort | novel peg 4000 derivatives and its use in controlled release of drug indomethacin |
| topic | polyethyleneglycol indomethacin incorporation controlled release |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600685&tlng=en |
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