Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide Novolacs
Herein we report new multiblock chalcone conjugate phthalimide and naphthalimide functionalized copolymers with a topologically novel architecture synthesis using nucleophilic substitution and polycondensation methodology. The structures of the synthesized novolacs were elucidated on the basis of th...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/11/1859 |
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| author | Periyan Durairaju Chinnasamy Umarani Govindasami Periyasami Perumberkandigai Adikesavan Vivekanand Mostafizur Rahaman |
| author_facet | Periyan Durairaju Chinnasamy Umarani Govindasami Periyasami Perumberkandigai Adikesavan Vivekanand Mostafizur Rahaman |
| author_sort | Periyan Durairaju |
| collection | DOAJ |
| description | Herein we report new multiblock chalcone conjugate phthalimide and naphthalimide functionalized copolymers with a topologically novel architecture synthesis using nucleophilic substitution and polycondensation methodology. The structures of the synthesized novolacs were elucidated on the basis of their spectroscopic analysis including FTIR, <sup>1</sup>H NMR, and <sup>13</sup>C NMR spectroscopy. Further, the number-average and weight-average molecular weights of the novolac polymers were determined by gel permeation chromatography (GPC). We examined the solubility of the synthesized polymers in various organic solvents including CHCl<sub>3</sub>, CH<sub>3</sub>CN, THF, H<sub>2</sub>O, CH<sub>3</sub>OH, DMSO, and DMF and found they are insoluble in both methanol and water. The novolac polymers were evaluated for their photophysical properties and microbial activities. The investigation of the antimicrobial activities of these polymers reveals significant antimicrobial activity against the pathogens <i>E. coli</i>, <i>S. aureus</i>, <i>C. albicans</i>, and <i>A. niger</i>. |
| first_indexed | 2024-03-10T10:45:27Z |
| format | Article |
| id | doaj.art-fc13574cd77e4e018de8befe0b3f1e9b |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T10:45:27Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-fc13574cd77e4e018de8befe0b3f1e9b2023-11-21T22:40:32ZengMDPI AGPolymers2073-43602021-06-011311185910.3390/polym13111859Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide NovolacsPeriyan Durairaju0Chinnasamy Umarani1Govindasami Periyasami2Perumberkandigai Adikesavan Vivekanand3Mostafizur Rahaman4Department of Chemistry, Thiruvalluvar Government Arts College, Namakkal 637401, IndiaDepartment of Chemistry, Government Arts College (Autonomous), Salem 636007, IndiaDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, Saveetha Engineering College, Chennai 602105, IndiaDepartment of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaHerein we report new multiblock chalcone conjugate phthalimide and naphthalimide functionalized copolymers with a topologically novel architecture synthesis using nucleophilic substitution and polycondensation methodology. The structures of the synthesized novolacs were elucidated on the basis of their spectroscopic analysis including FTIR, <sup>1</sup>H NMR, and <sup>13</sup>C NMR spectroscopy. Further, the number-average and weight-average molecular weights of the novolac polymers were determined by gel permeation chromatography (GPC). We examined the solubility of the synthesized polymers in various organic solvents including CHCl<sub>3</sub>, CH<sub>3</sub>CN, THF, H<sub>2</sub>O, CH<sub>3</sub>OH, DMSO, and DMF and found they are insoluble in both methanol and water. The novolac polymers were evaluated for their photophysical properties and microbial activities. The investigation of the antimicrobial activities of these polymers reveals significant antimicrobial activity against the pathogens <i>E. coli</i>, <i>S. aureus</i>, <i>C. albicans</i>, and <i>A. niger</i>.https://www.mdpi.com/2073-4360/13/11/1859N-substituted phthalimidefluorescent naphthalimidechalcone spacerphenol-formaldehyde resinsantimicrobial activity |
| spellingShingle | Periyan Durairaju Chinnasamy Umarani Govindasami Periyasami Perumberkandigai Adikesavan Vivekanand Mostafizur Rahaman Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide Novolacs Polymers N-substituted phthalimide fluorescent naphthalimide chalcone spacer phenol-formaldehyde resins antimicrobial activity |
| title | Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide Novolacs |
| title_full | Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide Novolacs |
| title_fullStr | Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide Novolacs |
| title_full_unstemmed | Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide Novolacs |
| title_short | Synthesis and In Vitro Antimicrobial Evaluation of Photoactive Multi—Block Chalcone Conjugate Phthalimide and 1,8-Naphthalimide Novolacs |
| title_sort | synthesis and in vitro antimicrobial evaluation of photoactive multi block chalcone conjugate phthalimide and 1 8 naphthalimide novolacs |
| topic | N-substituted phthalimide fluorescent naphthalimide chalcone spacer phenol-formaldehyde resins antimicrobial activity |
| url | https://www.mdpi.com/2073-4360/13/11/1859 |
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