Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration
Sphingosine-1-phosphate lyase (SPL) is a pyridoxal 5′-phosphate-dependent enzyme involved in the irreversible degradation of sphingosine-1-phosphate (S1P)—a bioactive sphingolipid that modulates a broad range of biological processes (cell proliferation, migration, differentiation and survival; mitoc...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/7/6180 |
| _version_ | 1797607923513294848 |
|---|---|
| author | Iga Wieczorek Robert Piotr Strosznajder |
| author_facet | Iga Wieczorek Robert Piotr Strosznajder |
| author_sort | Iga Wieczorek |
| collection | DOAJ |
| description | Sphingosine-1-phosphate lyase (SPL) is a pyridoxal 5′-phosphate-dependent enzyme involved in the irreversible degradation of sphingosine-1-phosphate (S1P)—a bioactive sphingolipid that modulates a broad range of biological processes (cell proliferation, migration, differentiation and survival; mitochondrial functioning; and gene expression). Although SPL activity leads to a decrease in the available pool of S1P in the cell, at the same time, hexadecenal and phosphoethanolamine, compounds with potential biological activity, are generated. The increased expression and/or activity of SPL, and hence the imbalance between S1P and the end products of its cleavage, were demonstrated in several pathological states. On the other hand, loss-of-function mutations in the SPL encoding gene are a cause of severe developmental impairments. Recently, special attention has been paid to neurodegenerative diseases as the most common pathologies of the nervous system. This review summarizes the current findings concerning the role of SPL in the nervous system with an emphasis on neurodegeneration. Moreover, it briefly discusses pharmacological compounds directed to inhibit its activity. |
| first_indexed | 2024-03-11T05:36:24Z |
| format | Article |
| id | doaj.art-fc13678e09db491ea39282a5265b926a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:36:24Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fc13678e09db491ea39282a5265b926a2023-11-17T16:47:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247618010.3390/ijms24076180Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in NeurodegenerationIga Wieczorek0Robert Piotr Strosznajder1Laboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, PolandLaboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawińskiego 5 St., 02-106 Warsaw, PolandSphingosine-1-phosphate lyase (SPL) is a pyridoxal 5′-phosphate-dependent enzyme involved in the irreversible degradation of sphingosine-1-phosphate (S1P)—a bioactive sphingolipid that modulates a broad range of biological processes (cell proliferation, migration, differentiation and survival; mitochondrial functioning; and gene expression). Although SPL activity leads to a decrease in the available pool of S1P in the cell, at the same time, hexadecenal and phosphoethanolamine, compounds with potential biological activity, are generated. The increased expression and/or activity of SPL, and hence the imbalance between S1P and the end products of its cleavage, were demonstrated in several pathological states. On the other hand, loss-of-function mutations in the SPL encoding gene are a cause of severe developmental impairments. Recently, special attention has been paid to neurodegenerative diseases as the most common pathologies of the nervous system. This review summarizes the current findings concerning the role of SPL in the nervous system with an emphasis on neurodegeneration. Moreover, it briefly discusses pharmacological compounds directed to inhibit its activity.https://www.mdpi.com/1422-0067/24/7/6180sphingosine-1-phospahte (S1P)S1P lyase (SPL)neurodegenerationneuroinflammationSPL inhibitors |
| spellingShingle | Iga Wieczorek Robert Piotr Strosznajder Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration International Journal of Molecular Sciences sphingosine-1-phospahte (S1P) S1P lyase (SPL) neurodegeneration neuroinflammation SPL inhibitors |
| title | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
| title_full | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
| title_fullStr | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
| title_full_unstemmed | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
| title_short | Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration |
| title_sort | recent insight into the role of sphingosine 1 phosphate lyase in neurodegeneration |
| topic | sphingosine-1-phospahte (S1P) S1P lyase (SPL) neurodegeneration neuroinflammation SPL inhibitors |
| url | https://www.mdpi.com/1422-0067/24/7/6180 |
| work_keys_str_mv | AT igawieczorek recentinsightintotheroleofsphingosine1phosphatelyaseinneurodegeneration AT robertpiotrstrosznajder recentinsightintotheroleofsphingosine1phosphatelyaseinneurodegeneration |