Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity Detection
Abnormal changes of intracellular microviscosity are associated with a series of pathologies and diseases. Therefore, monitoring viscosity at cellular and subcellular levels is important for pathological research. Fluorescent molecular rotors (FMRs) have recently been developed to detect viscosity t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00825/full |
| _version_ | 1818151410239275008 |
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| author | Wei Miao Changjiang Yu Erhong Hao Lijuan Jiao |
| author_facet | Wei Miao Changjiang Yu Erhong Hao Lijuan Jiao |
| author_sort | Wei Miao |
| collection | DOAJ |
| description | Abnormal changes of intracellular microviscosity are associated with a series of pathologies and diseases. Therefore, monitoring viscosity at cellular and subcellular levels is important for pathological research. Fluorescent molecular rotors (FMRs) have recently been developed to detect viscosity through a linear correlation between fluorescence intensity or lifetime and viscosity. Recently, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (boron dipyrrins or BODIPY) derivatives have been widely used to build FMRs for viscosity probes due to their high rotational ability of the rotor and potentially high brightness. In this minireview, functionalized BODIPYs as FMRs for viscosity detection were collected, analyzed and summarized. |
| first_indexed | 2024-12-11T13:38:23Z |
| format | Article |
| id | doaj.art-fc13dfaf27e64d36b3afd2f5cf829123 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-11T13:38:23Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-fc13dfaf27e64d36b3afd2f5cf8291232022-12-22T01:04:55ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-11-01710.3389/fchem.2019.00825488580Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity DetectionWei MiaoChangjiang YuErhong HaoLijuan JiaoAbnormal changes of intracellular microviscosity are associated with a series of pathologies and diseases. Therefore, monitoring viscosity at cellular and subcellular levels is important for pathological research. Fluorescent molecular rotors (FMRs) have recently been developed to detect viscosity through a linear correlation between fluorescence intensity or lifetime and viscosity. Recently, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (boron dipyrrins or BODIPY) derivatives have been widely used to build FMRs for viscosity probes due to their high rotational ability of the rotor and potentially high brightness. In this minireview, functionalized BODIPYs as FMRs for viscosity detection were collected, analyzed and summarized.https://www.frontiersin.org/article/10.3389/fchem.2019.00825/fullviscosityBODIPYfluorescent molecular rotorviscosimeterfluorescent probedyes |
| spellingShingle | Wei Miao Changjiang Yu Erhong Hao Lijuan Jiao Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity Detection Frontiers in Chemistry viscosity BODIPY fluorescent molecular rotor viscosimeter fluorescent probe dyes |
| title | Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity Detection |
| title_full | Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity Detection |
| title_fullStr | Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity Detection |
| title_full_unstemmed | Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity Detection |
| title_short | Functionalized BODIPYs as Fluorescent Molecular Rotors for Viscosity Detection |
| title_sort | functionalized bodipys as fluorescent molecular rotors for viscosity detection |
| topic | viscosity BODIPY fluorescent molecular rotor viscosimeter fluorescent probe dyes |
| url | https://www.frontiersin.org/article/10.3389/fchem.2019.00825/full |
| work_keys_str_mv | AT weimiao functionalizedbodipysasfluorescentmolecularrotorsforviscositydetection AT changjiangyu functionalizedbodipysasfluorescentmolecularrotorsforviscositydetection AT erhonghao functionalizedbodipysasfluorescentmolecularrotorsforviscositydetection AT lijuanjiao functionalizedbodipysasfluorescentmolecularrotorsforviscositydetection |