Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled Trial
BackgroundLanguage recovery is limited in moderate to severe post-stroke aphasia patients. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising tool in improving language dysfunctions caused by post-stroke aphasia, but the treatment outcome is as yet mixed. Considerable evi...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.909733/full |
| _version_ | 1811257782490365952 |
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| author | Kai Zheng Kai Zheng Kai Zheng Mingyun Chen Ying Shen Xinlei Xu Xinlei Xu Fanglan Gao Fanglan Gao Guilan Huang Guilan Huang Yingying Ji Yingying Ji Bin Su Bin Su Da Song Da Song Hui Fang Hui Fang Peng Liu Caili Ren Caili Ren |
| author_facet | Kai Zheng Kai Zheng Kai Zheng Mingyun Chen Ying Shen Xinlei Xu Xinlei Xu Fanglan Gao Fanglan Gao Guilan Huang Guilan Huang Yingying Ji Yingying Ji Bin Su Bin Su Da Song Da Song Hui Fang Hui Fang Peng Liu Caili Ren Caili Ren |
| author_sort | Kai Zheng |
| collection | DOAJ |
| description | BackgroundLanguage recovery is limited in moderate to severe post-stroke aphasia patients. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising tool in improving language dysfunctions caused by post-stroke aphasia, but the treatment outcome is as yet mixed. Considerable evidence has demonstrated the essential involvement of the cerebellum in a variety of language functions, suggesting that it may be a potential stimulation target of TMS for the treatment of post-stroke aphasia. Theta burst stimulation (TBS) is a specific pattern of rTMS with shorter stimulation times and better therapeutic effects. The effect of continuous TBS (cTBS) on the cerebellum in patients with aphasia with chronic stroke needs further exploration.MethodsIn this randomized, sham-controlled clinical trial, patients (n = 40) with chronic post-stroke aphasia received 10 sessions of real cTBS (n = 20) or sham cTBS (n = 20) over the right cerebellar Crus I+ a 30-min speech-language therapy. The Western Aphasia Battery (WAB) serves as the primary measure of the treatment outcome. The secondary outcome measures include the Boston Diagnostic Aphasia Examination, Boston Naming Test and speech acoustic parameters. Resting-state fMRI data were also obtained to examine treatment-induced changes in functional connectivity of the cerebro-cerebellar network. These outcome measures are assessed before, immediately after, and 12 weeks after cerebellar cTBS intervention.DiscussionThis protocol holds promise that cerebellar cTBS is a potential strategy to improve language functions in chronic post-stroke aphasia. The resting-state fMRI may explore the neural mechanism underlying the aphasia rehabilitation with cerebellar cTBS. |
| first_indexed | 2024-04-12T18:02:52Z |
| format | Article |
| id | doaj.art-fc1514438fa94618ad879687748e85da |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T18:02:52Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-fc1514438fa94618ad879687748e85da2022-12-22T03:22:05ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-06-011410.3389/fnagi.2022.909733909733Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled TrialKai Zheng0Kai Zheng1Kai Zheng2Mingyun Chen3Ying Shen4Xinlei Xu5Xinlei Xu6Fanglan Gao7Fanglan Gao8Guilan Huang9Guilan Huang10Yingying Ji11Yingying Ji12Bin Su13Bin Su14Da Song15Da Song16Hui Fang17Hui Fang18Peng Liu19Caili Ren20Caili Ren21Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Neurorehabilitation, Wuxi Tongren Rehabilitation Hospital, Wuxi, ChinaThe Affiliated Wuxi Mental Health Center of Nanjing Medical University, Wuxi, ChinaBackgroundLanguage recovery is limited in moderate to severe post-stroke aphasia patients. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising tool in improving language dysfunctions caused by post-stroke aphasia, but the treatment outcome is as yet mixed. Considerable evidence has demonstrated the essential involvement of the cerebellum in a variety of language functions, suggesting that it may be a potential stimulation target of TMS for the treatment of post-stroke aphasia. Theta burst stimulation (TBS) is a specific pattern of rTMS with shorter stimulation times and better therapeutic effects. The effect of continuous TBS (cTBS) on the cerebellum in patients with aphasia with chronic stroke needs further exploration.MethodsIn this randomized, sham-controlled clinical trial, patients (n = 40) with chronic post-stroke aphasia received 10 sessions of real cTBS (n = 20) or sham cTBS (n = 20) over the right cerebellar Crus I+ a 30-min speech-language therapy. The Western Aphasia Battery (WAB) serves as the primary measure of the treatment outcome. The secondary outcome measures include the Boston Diagnostic Aphasia Examination, Boston Naming Test and speech acoustic parameters. Resting-state fMRI data were also obtained to examine treatment-induced changes in functional connectivity of the cerebro-cerebellar network. These outcome measures are assessed before, immediately after, and 12 weeks after cerebellar cTBS intervention.DiscussionThis protocol holds promise that cerebellar cTBS is a potential strategy to improve language functions in chronic post-stroke aphasia. The resting-state fMRI may explore the neural mechanism underlying the aphasia rehabilitation with cerebellar cTBS.https://www.frontiersin.org/articles/10.3389/fnagi.2022.909733/fullstudy protocolaphasiacontinuous theta burst stimulationcerebellumrandomized controlled trial (RCT) |
| spellingShingle | Kai Zheng Kai Zheng Kai Zheng Mingyun Chen Ying Shen Xinlei Xu Xinlei Xu Fanglan Gao Fanglan Gao Guilan Huang Guilan Huang Yingying Ji Yingying Ji Bin Su Bin Su Da Song Da Song Hui Fang Hui Fang Peng Liu Caili Ren Caili Ren Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled Trial Frontiers in Aging Neuroscience study protocol aphasia continuous theta burst stimulation cerebellum randomized controlled trial (RCT) |
| title | Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled Trial |
| title_full | Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled Trial |
| title_fullStr | Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled Trial |
| title_full_unstemmed | Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled Trial |
| title_short | Cerebellar Continuous Theta Burst Stimulation for Aphasia Rehabilitation: Study Protocol for a Randomized Controlled Trial |
| title_sort | cerebellar continuous theta burst stimulation for aphasia rehabilitation study protocol for a randomized controlled trial |
| topic | study protocol aphasia continuous theta burst stimulation cerebellum randomized controlled trial (RCT) |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.909733/full |
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