Epigenetic Agents Trigger the Production of Bioactive Nucleoside Derivatives and Bisabolane Sesquiterpenes From the Marine-Derived Fungus Aspergillus versicolor

Epigenetic Agents Trigger the Production of Bioactive Nucleoside Derivatives and Bisabolane Sesquiterpenes From the Marine-Derived Fungus Aspergillus versicolor

Epigenetic agents, histone deacetylase inhibitor (SAHA) and DNA methyltransferase inhibitor (5-Aza), were added to Czapek-Dox medium to trigger the chemical diversity of marine-derived fungus Aspergillus versicolor XS-20090066. By HPLC and 1H NMR analysis, the diversity of fungal secondary metabolit...

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Bibliographic Details
Main Authors: Jing-Shuai Wu, Guang-Shan Yao, Xiao-Hui Shi, Saif Ur Rehman, Ying Xu, Xiu-Mei Fu, Xiu-Li Zhang, Yang Liu, Chang-Yun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Microbiology
Subjects:
histone deacetylase inhibitor
DNA methyltransferase inhibitor
Aspergillus versicolor
nucleoside derivatives
bisabolane sesquiterpenes
antibacterial activities
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00085/full

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