Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus
Background: Acute coronary syndrome is the most common disease in the world. Several studies suggest that hyperglycemia is associated with poor clinical outcomes in patients with coronary artery disease. The aim of this study was to investigate the impact of insulin infusion protocol and conventiona...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Iranian Journal of Nursing and Midwifery Research |
| Subjects: | |
| Online Access: | http://www.ijnmrjournal.net/article.asp?issn=1735-9066;year=2015;volume=20;issue=3;spage=304;epage=308;aulast=Sabouhi |
| _version_ | 1819264830693965824 |
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| author | Fakhri Sabouhi Mahboubeh Maleki Masoud Amini Maryam Kerdegari |
| author_facet | Fakhri Sabouhi Mahboubeh Maleki Masoud Amini Maryam Kerdegari |
| author_sort | Fakhri Sabouhi |
| collection | DOAJ |
| description | Background: Acute coronary syndrome is the most common disease in the world. Several studies suggest that hyperglycemia is associated with poor clinical outcomes in patients with coronary artery disease. The aim of this study was to investigate the impact of insulin infusion protocol and conventional therapy on the blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus.
Materials and Methods: We studied 64 patients (32 in each group) with acute coronary syndrome and acute myocardial infarction, who were admitted to the coronary care unit in a hospital in Isfahan, Iran in 2012. Inclusion criterion was blood sugar (BS) of more than 180 mg/dl on admission. Patients in the intervention group received insulin with East Jefferson insulin infusion protocol for at least 4 h, and in the control group, the subjects received subcutaneous insulin (conventional therapy) for at least for 48 h. Independent t-test, Student′s t-test, and Chi-square test were used to analyze the data.
Results: Groups were matched for baseline characteristics. Blood glucose was significantly reduced in the two groups ( P < 0.001), and the mean blood glucose level in the interaction group was significantly less than in the control group ( P = 0.0002).
Hypoglycemia was 31.2% and 25% in the intervention and control groups, respectively. The frequency of hypoglycemia did not differ significantly between the two groups ( P = 0.75). Time to reach target insulin level differed between the two groups (4.75 h in the intervention group and 36.93 h in the control group; P < 0.001).
Conclusions: Our research showed that use of insulin infusion protocol is better in maintaining glycemia control compared to subcutaneous sliding scale method. The protocol allows nurses to commence and maintain the infusion more effectively and safely compared to the traditional method. |
| first_indexed | 2024-12-23T20:35:43Z |
| format | Article |
| id | doaj.art-fc1711860d8643fe8812f427258f3562 |
| institution | Directory Open Access Journal |
| issn | 1735-9066 |
| language | English |
| last_indexed | 2024-12-23T20:35:43Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Iranian Journal of Nursing and Midwifery Research |
| spelling | doaj.art-fc1711860d8643fe8812f427258f35622022-12-21T17:32:05ZengWolters Kluwer Medknow PublicationsIranian Journal of Nursing and Midwifery Research1735-90662015-01-01203304308Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitusFakhri SabouhiMahboubeh MalekiMasoud AminiMaryam KerdegariBackground: Acute coronary syndrome is the most common disease in the world. Several studies suggest that hyperglycemia is associated with poor clinical outcomes in patients with coronary artery disease. The aim of this study was to investigate the impact of insulin infusion protocol and conventional therapy on the blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus. Materials and Methods: We studied 64 patients (32 in each group) with acute coronary syndrome and acute myocardial infarction, who were admitted to the coronary care unit in a hospital in Isfahan, Iran in 2012. Inclusion criterion was blood sugar (BS) of more than 180 mg/dl on admission. Patients in the intervention group received insulin with East Jefferson insulin infusion protocol for at least 4 h, and in the control group, the subjects received subcutaneous insulin (conventional therapy) for at least for 48 h. Independent t-test, Student′s t-test, and Chi-square test were used to analyze the data. Results: Groups were matched for baseline characteristics. Blood glucose was significantly reduced in the two groups ( P < 0.001), and the mean blood glucose level in the interaction group was significantly less than in the control group ( P = 0.0002). Hypoglycemia was 31.2% and 25% in the intervention and control groups, respectively. The frequency of hypoglycemia did not differ significantly between the two groups ( P = 0.75). Time to reach target insulin level differed between the two groups (4.75 h in the intervention group and 36.93 h in the control group; P < 0.001). Conclusions: Our research showed that use of insulin infusion protocol is better in maintaining glycemia control compared to subcutaneous sliding scale method. The protocol allows nurses to commence and maintain the infusion more effectively and safely compared to the traditional method.http://www.ijnmrjournal.net/article.asp?issn=1735-9066;year=2015;volume=20;issue=3;spage=304;epage=308;aulast=SabouhiAcute coronary syndromediabetes mellitusinsulin infusion systemsIrannursing |
| spellingShingle | Fakhri Sabouhi Mahboubeh Maleki Masoud Amini Maryam Kerdegari Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus Iranian Journal of Nursing and Midwifery Research Acute coronary syndrome diabetes mellitus insulin infusion systems Iran nursing |
| title | Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus |
| title_full | Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus |
| title_fullStr | Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus |
| title_full_unstemmed | Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus |
| title_short | Impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus |
| title_sort | impacts of insulin infusion protocol on blood glucose level and outcomes in acute coronary syndrome patients with diabetes mellitus |
| topic | Acute coronary syndrome diabetes mellitus insulin infusion systems Iran nursing |
| url | http://www.ijnmrjournal.net/article.asp?issn=1735-9066;year=2015;volume=20;issue=3;spage=304;epage=308;aulast=Sabouhi |
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