Inflammation and mitophagy are mitochondrial checkpoints to aging
Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a pr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-47840-1 |
| _version_ | 1797199372348293120 |
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| author | Emma Guilbaud Kristopher A. Sarosiek Lorenzo Galluzzi |
| author_facet | Emma Guilbaud Kristopher A. Sarosiek Lorenzo Galluzzi |
| author_sort | Emma Guilbaud |
| collection | DOAJ |
| description | Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy. |
| first_indexed | 2024-04-24T07:14:42Z |
| format | Article |
| id | doaj.art-fc179bd8f28f4dd99248eccc115c6d20 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T07:14:42Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fc179bd8f28f4dd99248eccc115c6d202024-04-21T11:24:14ZengNature PortfolioNature Communications2041-17232024-04-011511310.1038/s41467-024-47840-1Inflammation and mitophagy are mitochondrial checkpoints to agingEmma Guilbaud0Kristopher A. Sarosiek1Lorenzo Galluzzi2Department of Radiation Oncology, Weill Cornell MedicineJohn B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public HealthDepartment of Radiation Oncology, Weill Cornell MedicineCellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.https://doi.org/10.1038/s41467-024-47840-1 |
| spellingShingle | Emma Guilbaud Kristopher A. Sarosiek Lorenzo Galluzzi Inflammation and mitophagy are mitochondrial checkpoints to aging Nature Communications |
| title | Inflammation and mitophagy are mitochondrial checkpoints to aging |
| title_full | Inflammation and mitophagy are mitochondrial checkpoints to aging |
| title_fullStr | Inflammation and mitophagy are mitochondrial checkpoints to aging |
| title_full_unstemmed | Inflammation and mitophagy are mitochondrial checkpoints to aging |
| title_short | Inflammation and mitophagy are mitochondrial checkpoints to aging |
| title_sort | inflammation and mitophagy are mitochondrial checkpoints to aging |
| url | https://doi.org/10.1038/s41467-024-47840-1 |
| work_keys_str_mv | AT emmaguilbaud inflammationandmitophagyaremitochondrialcheckpointstoaging AT kristopherasarosiek inflammationandmitophagyaremitochondrialcheckpointstoaging AT lorenzogalluzzi inflammationandmitophagyaremitochondrialcheckpointstoaging |