The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells
Diabetic neuropathy (DN) is a common complication of diabetes mellitus resulting in cognitive dysfunction and synaptic plasticity impairment. Hyperglycemia plays a critical role in the development and progression of DN, through a number of mechanisms including increased oxidative stress. Cannabinoid...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2007-08-01
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| Series: | Neurobiology of Disease |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996107000848 |
| _version_ | 1818417558912499712 |
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| author | Yossi Dagon Yosefa Avraham Gabriela Link Olga Zolotarev Raphael Mechoulam Elliot M. Berry |
| author_facet | Yossi Dagon Yosefa Avraham Gabriela Link Olga Zolotarev Raphael Mechoulam Elliot M. Berry |
| author_sort | Yossi Dagon |
| collection | DOAJ |
| description | Diabetic neuropathy (DN) is a common complication of diabetes mellitus resulting in cognitive dysfunction and synaptic plasticity impairment. Hyperglycemia plays a critical role in the development and progression of DN, through a number of mechanisms including increased oxidative stress. Cannabinoids are a diverse family of compounds which can act as antioxidative agents and exhibit neuroprotective properties. We investigated the effect of the synthetic cannabinoid HU-210 on brain function of streptozotocin (STZ)-induced diabetic mice. These animals exhibit hyperglycemia, increased cerebral oxidative stress and impaired brain function. HU-210, through a receptor independent pathway, alleviates the oxidative damage and cognitive impairment without affecting glycemic control. To study the neuroprotective mechanism(s) involved, we cultured PC12 cells under hyperglycemic conditions. Hyperglycemia enhanced oxidative stress and cellular injuries were all counteracted by HU-210—in a dose dependent manner. These results suggest cannabinoids might have a therapeutic role in the management of the neurological complications of diabetes. |
| first_indexed | 2024-12-14T12:08:42Z |
| format | Article |
| id | doaj.art-fc1af28914a947518fd829d3a21032b4 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-14T12:08:42Z |
| publishDate | 2007-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-fc1af28914a947518fd829d3a21032b42022-12-21T23:01:48ZengElsevierNeurobiology of Disease1095-953X2007-08-01272174181The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cellsYossi Dagon0Yosefa Avraham1Gabriela Link2Olga Zolotarev3Raphael Mechoulam4Elliot M. Berry5Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University, Hadassah Medical School, IsraelDepartment of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University, Hadassah Medical School, IsraelDepartment of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University, Hadassah Medical School, IsraelDepartment of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University, Hadassah Medical School, IsraelDepartment of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University Jerusalem, 91120, IsraelDepartment of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine Hebrew University, Hadassah Medical School, Israel; Corresponding author. Fax: +972 2 6431105.Diabetic neuropathy (DN) is a common complication of diabetes mellitus resulting in cognitive dysfunction and synaptic plasticity impairment. Hyperglycemia plays a critical role in the development and progression of DN, through a number of mechanisms including increased oxidative stress. Cannabinoids are a diverse family of compounds which can act as antioxidative agents and exhibit neuroprotective properties. We investigated the effect of the synthetic cannabinoid HU-210 on brain function of streptozotocin (STZ)-induced diabetic mice. These animals exhibit hyperglycemia, increased cerebral oxidative stress and impaired brain function. HU-210, through a receptor independent pathway, alleviates the oxidative damage and cognitive impairment without affecting glycemic control. To study the neuroprotective mechanism(s) involved, we cultured PC12 cells under hyperglycemic conditions. Hyperglycemia enhanced oxidative stress and cellular injuries were all counteracted by HU-210—in a dose dependent manner. These results suggest cannabinoids might have a therapeutic role in the management of the neurological complications of diabetes.http://www.sciencedirect.com/science/article/pii/S0969996107000848 |
| spellingShingle | Yossi Dagon Yosefa Avraham Gabriela Link Olga Zolotarev Raphael Mechoulam Elliot M. Berry The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells Neurobiology of Disease |
| title | The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells |
| title_full | The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells |
| title_fullStr | The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells |
| title_full_unstemmed | The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells |
| title_short | The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells |
| title_sort | synthetic cannabinoid hu 210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma pc12 cells |
| url | http://www.sciencedirect.com/science/article/pii/S0969996107000848 |
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